Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Guoxin Wu; Paul Zuck; Shih Lin Goh; Jeffrey M. Milush; Poonam Vohra; Joseph K. Wong; Ma Somsouk; Steven A. Yukl; Barbara L. Shacklett; Nicolas Chomont; Ashley T. Haase; Hiroyu Hatano; Timothy W. Schacker; Steven G. Deeks; Daria J. Hazuda; Peter W. Hunt; Bonnie J. Howell

doi:10.1093/infdis/jiab121

Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Guoxin Wu, Paul Zuck, Shih Lin Goh, Jeffrey M. Milush, Poonam Vohra, Joseph K. Wong, Ma Somsouk, Steven A. Yukl, Barbara L. Shacklett, Nicolas Chomont, Ashley T. Haase, Hiroyu Hatano, Timothy W. Schacker, Steven G. Deeks, Daria J. Hazuda, Peter W. Hunt, Bonnie J. Howell

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Abstract

We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

Original language	English (US)
Pages (from-to)	1593-1598
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	224
Issue number	9
DOIs	https://doi.org/10.1093/infdis/jiab121
State	Published - Nov 1 2021

Bibliographical note

Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Keywords

HIV
HIV persistence
biomarker
fine needle aspirates
gag p24
lymph nodes
rectal biopsy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Wu, G., Zuck, P., Goh, S. L., Milush, J. M., Vohra, P., Wong, J. K., Somsouk, M., Yukl, S. A., Shacklett, B. L., Chomont, N., Haase, A. T., Hatano, H., Schacker, T. W., Deeks, S. G., Hazuda, D. J., Hunt, P. W., & Howell, B. J. (2021). Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response. Journal of Infectious Diseases, 224(9), 1593-1598. https://doi.org/10.1093/infdis/jiab121

Wu, G, Zuck, P, Goh, SL, Milush, JM, Vohra, P, Wong, JK, Somsouk, M, Yukl, SA, Shacklett, BL, Chomont, N, Haase, AT, Hatano, H, Schacker, TW, Deeks, SG, Hazuda, DJ, Hunt, PW & Howell, BJ 2021, 'Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response', Journal of Infectious Diseases, vol. 224, no. 9, pp. 1593-1598. https://doi.org/10.1093/infdis/jiab121

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abstract = "We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.",

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AU - Vohra, Poonam

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AU - Schacker, Timothy W.

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AU - Hazuda, Daria J.

AU - Hunt, Peter W.

AU - Howell, Bonnie J.

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AB - We demonstrate that human immunodeficiency virus (HIV) gag p24 protein is more readily detected in gut and lymph node tissues than in blood CD4+ T cells and correlates better with CD4 count during antiretroviral therapy (ART). Gut p24 levels also measurably decline with ART in natural controllers. During ART, gut p24 expression is more strongly associated both with HIV-specific CD8+ T-cell frequency and plasma soluble CD14 levels than gut HIV RNA expression. This study supports using gag p24 as a marker of HIV expression in HIV+ tissues to study effects of viral persistence and to monitor efficacy of treatment in HIV-based clearance studies.

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Gag p24 Is a Marker of Human Immunodeficiency Virus Expression in Tissues and Correlates with Immune Response

Abstract

Bibliographical note

Keywords

UN SDGs

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