TY - JOUR
T1 - Genetic architecture of tameness in a rat model of animal domestication
AU - Albert, Frank W.
AU - Carlborg, Örjan
AU - Plyusnina, Irina
AU - Besnier, Francois
AU - Hedwig, Daniela
AU - Lautenschläger, Susann
AU - Lorenz, Doreen
AU - McIntosh, Jenny
AU - Neumann, Christof
AU - Richter, Henning
AU - Zeising, Claudia
AU - Kozhemyakina, Rimma
AU - Shchepina, Olesya
AU - Kratzsch, Jürgen
AU - Trut, Lyudmila
AU - Teupser, Daniel
AU - Thiery, Joachim
AU - Schöneberg, Torsten
AU - Andersson, Leif
AU - Pääbo, Svante
PY - 2009/6
Y1 - 2009/6
N2 - A common feature of domestic animals is tameness - i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.
AB - A common feature of domestic animals is tameness - i.e., they tolerate and are unafraid of human presence and handling. To gain insight into the genetic basis of tameness and aggression, we studied an intercross between two lines of rats (Rattus norvegicus) selected over >60 generations for increased tameness and increased aggression against humans, respectively. We measured 45 traits, including tameness and aggression, anxiety-related traits, organ weights, and levels of serum components in >700 rats from an intercross population. Using 201 genetic markers, we identified two significant quantitative trait loci (QTL) for tameness. These loci overlap with QTL for adrenal gland weight and for anxiety-related traits and are part of a five-locus epistatic network influencing tameness. An additional QTL influences the occurrence of white coat spots, but shows no significant effect on tameness. The loci described here are important starting points for finding the genes that cause tameness in these rats and potentially in domestic animals in general.
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U2 - 10.1534/genetics.109.102186
DO - 10.1534/genetics.109.102186
M3 - Article
C2 - 19363126
AN - SCOPUS:68949198769
SN - 0016-6731
VL - 182
SP - 541
EP - 554
JO - Genetics
JF - Genetics
IS - 2
ER -