TY - JOUR
T1 - Genetic identification by mass spectrometric analysis of single-nucleotide polymorphisms
T2 - Ternary encoding of genotypes
AU - Griffin, Timothy J.
AU - Smith, Lloyd M.
PY - 2000/7/15
Y1 - 2000/7/15
N2 - An approach to genetic identification using biallelic single-nucleotide polymorphism (SNP) genetic markers is described in which the three possible genotypes, AA, Aa, or aa, where 'A' and 'a' represent the two SNP alleles, are assigned a ternary (base 3) digit of 0, 1, or 2, respectively. Genotyping an individual over a panel of separate SNP markers produces a composite ternary genetic code that can be converted to an easily stored, decimal (base 10) genetic identification number. The unambiguous identification of 11 individuals is demonstrated using ternary genetic codes generated from MALDI-TOF mass spectrometric genotyping data from 7 different SNP markers.
AB - An approach to genetic identification using biallelic single-nucleotide polymorphism (SNP) genetic markers is described in which the three possible genotypes, AA, Aa, or aa, where 'A' and 'a' represent the two SNP alleles, are assigned a ternary (base 3) digit of 0, 1, or 2, respectively. Genotyping an individual over a panel of separate SNP markers produces a composite ternary genetic code that can be converted to an easily stored, decimal (base 10) genetic identification number. The unambiguous identification of 11 individuals is demonstrated using ternary genetic codes generated from MALDI-TOF mass spectrometric genotyping data from 7 different SNP markers.
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U2 - 10.1021/ac991390e
DO - 10.1021/ac991390e
M3 - Article
C2 - 10939403
AN - SCOPUS:0034661534
SN - 0003-2700
VL - 72
SP - 3298
EP - 3302
JO - Analytical chemistry
JF - Analytical chemistry
IS - 14
ER -