Genomic analysis and treatment response of a bladder urothelial carcinoma with sarcomatoid variant histology

Vikram M. Narayan; Shilpa Gupta; Elai Davicioni; Paari Murugan; Ewan A. Gibb; Badrinath Konety

doi:10.1016/j.clgc.2019.05.019

Genomic analysis and treatment response of a bladder urothelial carcinoma with sarcomatoid variant histology

Vikram M. Narayan, Shilpa Gupta, Elai Davicioni, Paari Murugan, Ewan A. Gibb, Badrinath Konety

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Abstract

The sarcomatoid variant of bladder cancer has a reported prevalence of 0.3-0.6% of all bladder cancers.1–3 Risk factors that have been reported for the development of sarcomatoid differentiation include prior exposure to cyclophosphamide therapy and radiation therapy.4,5 This variant has been associated with aggressive disease and poor response to chemotherapy, suggesting that immediate radical cystectomy would be appropriate as first line therapy for patients with localized disease.6–8

Original language	English (US)
Journal	Clinical Genitourinary Cancer
DOIs	https://doi.org/10.1016/j.clgc.2019.05.019
State	E-pub ahead of print - May 25 2019

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https://linkinghub.elsevier.com/retrieve/pii/S1558767319301570

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title = "Genomic analysis and treatment response of a bladder urothelial carcinoma with sarcomatoid variant histology",

abstract = "The sarcomatoid variant of bladder cancer has a reported prevalence of 0.3-0.6% of all bladder cancers.1–3 Risk factors that have been reported for the development of sarcomatoid differentiation include prior exposure to cyclophosphamide therapy and radiation therapy.4,5 This variant has been associated with aggressive disease and poor response to chemotherapy, suggesting that immediate radical cystectomy would be appropriate as first line therapy for patients with localized disease.6–8",

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AU - Narayan, Vikram M.

AU - Gupta, Shilpa

AU - Davicioni, Elai

AU - Murugan, Paari

AU - Gibb, Ewan A.

AU - Konety, Badrinath

PY - 2019/5/25

Y1 - 2019/5/25

N2 - The sarcomatoid variant of bladder cancer has a reported prevalence of 0.3-0.6% of all bladder cancers.1–3 Risk factors that have been reported for the development of sarcomatoid differentiation include prior exposure to cyclophosphamide therapy and radiation therapy.4,5 This variant has been associated with aggressive disease and poor response to chemotherapy, suggesting that immediate radical cystectomy would be appropriate as first line therapy for patients with localized disease.6–8

AB - The sarcomatoid variant of bladder cancer has a reported prevalence of 0.3-0.6% of all bladder cancers.1–3 Risk factors that have been reported for the development of sarcomatoid differentiation include prior exposure to cyclophosphamide therapy and radiation therapy.4,5 This variant has been associated with aggressive disease and poor response to chemotherapy, suggesting that immediate radical cystectomy would be appropriate as first line therapy for patients with localized disease.6–8

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DO - 10.1016/j.clgc.2019.05.019

M3 - Article

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JF - Clinical Genitourinary Cancer

ER -

Genomic analysis and treatment response of a bladder urothelial carcinoma with sarcomatoid variant histology

Abstract

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UN SDGs

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