Abstract
We found that glia secrete myoglianin, a TGF-β2 ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.
Original language | English (US) |
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Pages (from-to) | 821-823 |
Number of pages | 3 |
Journal | Nature neuroscience |
Volume | 14 |
Issue number | 7 |
DOIs | |
State | Published - Jul 2011 |