Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)

Paul Erhardt; Kenneth Bachmann; Donald Birkett; Michael Boberg; Nicholas Bodor; Gordon Gibson; David Hawkins; Gabrielle Hawksworth; Jack Hinson; Daniel Koehler; Brian Kress; Amarjit Luniwal; Hiroshi Masumoto; Raymond Novak; Phillip Portoghese; Jeffrey Sarver; M. Teresa Serafini; Christopher Trabbic; Nico Vermeulen; Steven Wrighton

doi:10.1515/pac-2018-0208

Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)

Paul Erhardt, Kenneth Bachmann, Donald Birkett, Michael Boberg, Nicholas Bodor, Gordon Gibson, David Hawkins, Gabrielle Hawksworth, Jack Hinson, Daniel Koehler, Brian Kress, Amarjit Luniwal, Hiroshi Masumoto, Raymond Novak, Phillip Portoghese, Jeffrey Sarver, M. Teresa Serafini, Christopher Trabbic, Nico Vermeulen, Steven Wrighton

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today's highly multidisciplinary, collaborative small molecule drug discovery teams.

Original language	English (US)
Pages (from-to)	273-403
Number of pages	131
Journal	Pure and Applied Chemistry
Volume	93
Issue number	3
DOIs	https://doi.org/10.1515/pac-2018-0208
State	Published - Mar 1 2021

Bibliographical note

Publisher Copyright:
© 2021 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/ 2021.

Keywords

absorption
bioanalytical methods
biodegradation
drug delivery
drug design
drug discovery
environmental chemistry
enzyme chemistry
medicinal chemistry
metabolism
oxidation
pharmaceuticals

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Erhardt, P., Bachmann, K., Birkett, D., Boberg, M., Bodor, N., Gibson, G., Hawkins, D., Hawksworth, G., Hinson, J., Koehler, D., Kress, B., Luniwal, A., Masumoto, H., Novak, R., Portoghese, P., Sarver, J., Serafini, M. T., Trabbic, C., Vermeulen, N., & Wrighton, S. (2021). Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report). Pure and Applied Chemistry, 93(3), 273-403. https://doi.org/10.1515/pac-2018-0208

Erhardt, P, Bachmann, K, Birkett, D, Boberg, M, Bodor, N, Gibson, G, Hawkins, D, Hawksworth, G, Hinson, J, Koehler, D, Kress, B, Luniwal, A, Masumoto, H, Novak, R, Portoghese, P, Sarver, J, Serafini, MT, Trabbic, C, Vermeulen, N & Wrighton, S 2021, 'Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)', Pure and Applied Chemistry, vol. 93, no. 3, pp. 273-403. https://doi.org/10.1515/pac-2018-0208

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Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)

Abstract

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Keywords

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