Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes

Medicine & Life Sciences

• Liver Microsomes 100%
• hydroxide ion 99%
• Amines 91%
• Glucuronides 29%
• 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine 22%
• 2-hydroxyamino-6-methyldipyrido(1,2-a-3',2'-d)imidazole 21%
• 2',3-dimethyl-4-aminobiphenyl 18%
• Uridine Diphosphate Glucuronic Acid 15%
• Dogs 14%
• 2-phenylimidazo(4,5-b)pyridine 12%
• Glucuronidase 12%
• Glu-P-2 9%
• Carcinogens 9%
• 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole 9%
• 2-amino-3-methylimidazo(4,5-f)quinoline 8%
• Fast Atom Bombardment Mass Spectrometry 8%
• Liver 7%
• Quinoxalines 7%
• Glucuronosyltransferase 6%
• imidazole 6%
• Microsomes 5%
• Hydrolysis 4%
• Ions 4%
• High Pressure Liquid Chromatography 3%
• Colon 3%
• Urinary Bladder 3%
• Food 3%