Graphite oxide: A selective and highly efficient oxidant of thiols and sulfides

Daniel R. Dreyer; Hong Peng Jia; Alexander D. Todd; Jianxin Geng; Christopher W. Bielawski

doi:10.1039/c1ob06102j

Graphite oxide: A selective and highly efficient oxidant of thiols and sulfides

Daniel R. Dreyer, Hong Peng Jia, Alexander D. Todd, Jianxin Geng, Christopher W. Bielawski

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Abstract

The selective oxidation of thiols to disulfides and sulfides to sulfoxides using graphite oxide (GO), a heterogeneous carbocatalyst obtained from low cost, commercial starting materials is described. The aforementioned oxidation reactions were found to proceed rapidly (as short as 10 min in some cases) and in good yield (51-100%) (19 examples). No over-oxidation of the substrates was observed, and GO's heterogeneous nature facilitated isolation and purification of the target products.

Original language	English (US)
Pages (from-to)	7292-7295
Number of pages	4
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	21
DOIs	https://doi.org/10.1039/c1ob06102j
State	Published - Nov 7 2011
Externally published	Yes

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abstract = "The selective oxidation of thiols to disulfides and sulfides to sulfoxides using graphite oxide (GO), a heterogeneous carbocatalyst obtained from low cost, commercial starting materials is described. The aforementioned oxidation reactions were found to proceed rapidly (as short as 10 min in some cases) and in good yield (51-100%) (19 examples). No over-oxidation of the substrates was observed, and GO's heterogeneous nature facilitated isolation and purification of the target products.",

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AU - Dreyer, Daniel R.

AU - Jia, Hong Peng

AU - Todd, Alexander D.

AU - Geng, Jianxin

AU - Bielawski, Christopher W.

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AB - The selective oxidation of thiols to disulfides and sulfides to sulfoxides using graphite oxide (GO), a heterogeneous carbocatalyst obtained from low cost, commercial starting materials is described. The aforementioned oxidation reactions were found to proceed rapidly (as short as 10 min in some cases) and in good yield (51-100%) (19 examples). No over-oxidation of the substrates was observed, and GO's heterogeneous nature facilitated isolation and purification of the target products.

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Graphite oxide: A selective and highly efficient oxidant of thiols and sulfides

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