TY - JOUR
T1 - Heparin kinetics during hemodialysis
T2 - Variation in sensitivity, distribution volume, and dosage
AU - Seifert, Randall
AU - Borchert, Wanda
AU - Letendre, Peter
AU - Knutson, Russell
AU - Cipolle, Robert
PY - 1986
Y1 - 1986
N2 - A method to assess heparin kinetics and individualize dosages was examined in 27 patients during chronic hemodialysis. Pretreatment heparin sensitivities were determined to establish the relationship between heparin concentration and activated clotting times (ACTs). Distribution volume was calculated by dividing the heparin loading dose by the 5-min heparin concentration. Assessments were made during three different dialysis periods. There was a 10-fold range in pretreatment heparin sensitivities. Intrapatient heparin sensitivity remained relatively consistent between dialysis periods. The degree of heparin sensitivity was significantly correlated to baseline ACT. Patients post-splenectomy were more sensitive to heparin. Large intra- and interpatient variation in distribution volume was also observed. Men, patients, <60 years old, and patients post-splenectomy represented variables that contributed to higher heparin dose requirements.
AB - A method to assess heparin kinetics and individualize dosages was examined in 27 patients during chronic hemodialysis. Pretreatment heparin sensitivities were determined to establish the relationship between heparin concentration and activated clotting times (ACTs). Distribution volume was calculated by dividing the heparin loading dose by the 5-min heparin concentration. Assessments were made during three different dialysis periods. There was a 10-fold range in pretreatment heparin sensitivities. Intrapatient heparin sensitivity remained relatively consistent between dialysis periods. The degree of heparin sensitivity was significantly correlated to baseline ACT. Patients post-splenectomy were more sensitive to heparin. Large intra- and interpatient variation in distribution volume was also observed. Men, patients, <60 years old, and patients post-splenectomy represented variables that contributed to higher heparin dose requirements.
UR - http://www.scopus.com/inward/record.url?scp=0022651057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022651057&partnerID=8YFLogxK
U2 - 10.1097/00007691-198603000-00007
DO - 10.1097/00007691-198603000-00007
M3 - Article
C2 - 3961894
AN - SCOPUS:0022651057
SN - 0163-4356
VL - 8
SP - 32
EP - 36
JO - Therapeutic Drug Monitoring
JF - Therapeutic Drug Monitoring
IS - 1
ER -