Hepatitis b-related hepatocellular carcinoma: Surveillance strategy directed by immune-epidemiology

Chimaobi M. Anugwom; Manon Allaire; Sheikh Mohammad Fazle Akbar; Amir Sultan; Steven Bollipo; Angelo Z. Mattos; Jose D. Debes

doi:10.20517/2394-5079.2021.06

Hepatitis b-related hepatocellular carcinoma: Surveillance strategy directed by immune-epidemiology

Chimaobi M. Anugwom, Manon Allaire, Sheikh Mohammad Fazle Akbar, Amir Sultan, Steven Bollipo, Angelo Z. Mattos, Jose D. Debes

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.

Original language	English (US)
Article number	23
Journal	Hepatoma Research
Volume	7
DOIs	https://doi.org/10.20517/2394-5079.2021.06
State	Published - 2021

Bibliographical note

Publisher Copyright:
© The Author(s) 2021.

Keywords

Continent
HBV
HCC
Risk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Hepatitis b-related hepatocellular carcinoma: Surveillance strategy directed by immune-epidemiology",

abstract = "Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.",

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journal = "Hepatoma Research",

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T2 - Surveillance strategy directed by immune-epidemiology

AU - Anugwom, Chimaobi M.

AU - Allaire, Manon

AU - Akbar, Sheikh Mohammad Fazle

AU - Sultan, Amir

AU - Bollipo, Steven

AU - Mattos, Angelo Z.

AU - Debes, Jose D.

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2021

Y1 - 2021

N2 - Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.

AB - Hepatitis B infection (HBV) is one of the most common causes of hepatocellular carcinoma (HCC) worldwide. The age of occurrence, prognosis and incidence vary dramatically depending on the region of the world. This geographic variation is largely dependent on the contrasting incidence of HBV, age of transmission of the virus, the timing of integration into the human genome, and different HBV genotypes, as well as environmental factors. It results in a wide difference in viral interaction with the immune system, genomic modulation and the consequent development of HCC in an individual. In this review, we describe many factors implicated in HCC development, provide insight regarding at-risk populations and explain societal recommendations for HCC surveillance in persons living with HBV in different continents of the world.

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KW - HBV

KW - HCC

KW - Risk

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ER -

Hepatitis b-related hepatocellular carcinoma: Surveillance strategy directed by immune-epidemiology

Abstract

Bibliographical note

Keywords

UN SDGs

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