TY - JOUR
T1 - High Number of Memory T Cells Is Associated with Higher Risk of Acute Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation
AU - Loschi, Michael
AU - Porcher, Raphael
AU - Peffault de Latour, Regis
AU - Vanneaux, Valerie
AU - Robin, Marie
AU - Xhaard, Alienor
AU - Sicre de Fontebrune, Flore
AU - Larghero, Jerome
AU - Socie, Gerard
N1 - Publisher Copyright:
© 2015 American Society for Blood and Marrow Transplantation.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - The pathophysiology of acute graft-versus-host disease (GVHD) remains poorly understood in humans. Although T cell subsets have been identified to play a major role in disease initiation in rodents, clinical data on the effect of these different subsets are scarce and conflicting. To address this question, immunophenotyping analyses were performed on the graft in 210 patients. The onset of acute GVHD was retrospectively correlated with these subpopulations. In an adjusted analysis, only the absolute count of CD45lo/CD62Llo CD8+ T cells (effector memory T cells) was significantly associated with the onset of grade 2 to 4 acute GVHD. Thus, in contrast to experimental data, we found that the number of effector memory but not of naïve T cells was associated with the onset of GVHD. These results should be kept in mind while clinical trials, which aim to deplete naïve T cells, are underway in several institutions.
AB - The pathophysiology of acute graft-versus-host disease (GVHD) remains poorly understood in humans. Although T cell subsets have been identified to play a major role in disease initiation in rodents, clinical data on the effect of these different subsets are scarce and conflicting. To address this question, immunophenotyping analyses were performed on the graft in 210 patients. The onset of acute GVHD was retrospectively correlated with these subpopulations. In an adjusted analysis, only the absolute count of CD45lo/CD62Llo CD8+ T cells (effector memory T cells) was significantly associated with the onset of grade 2 to 4 acute GVHD. Thus, in contrast to experimental data, we found that the number of effector memory but not of naïve T cells was associated with the onset of GVHD. These results should be kept in mind while clinical trials, which aim to deplete naïve T cells, are underway in several institutions.
KW - Acute graft-versus-host disease
KW - Memory T cell
KW - Naïve T cell
KW - Stem cell transplantation
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UR - http://www.scopus.com/inward/citedby.url?scp=84922769510&partnerID=8YFLogxK
U2 - 10.1016/j.bbmt.2014.12.009
DO - 10.1016/j.bbmt.2014.12.009
M3 - Article
C2 - 25528387
AN - SCOPUS:84922769510
SN - 1083-8791
VL - 21
SP - 569
EP - 574
JO - Biology of Blood and Marrow Transplantation
JF - Biology of Blood and Marrow Transplantation
IS - 3
ER -