TY - JOUR
T1 - High-throughput processing to preserve viable cells
T2 - A precision medicine initiative cohort program workshop
AU - Rasooly, Rebekah S.
AU - Gossett, Daniel R.
AU - Henderson, Marianne K.
AU - Hubel, Allison
AU - Thibodeau, Stephen N.
N1 - Publisher Copyright:
© Mary Ann Liebert, Inc. 2017.
PY - 2017/8
Y1 - 2017/8
N2 - Conventionally, biobanks supporting clinical research studies have preserved serum, plasma, urine, saliva, a variety of tissue types, and stool. With the emergence of increasingly sophisticated technologies for analyzing single cells, there is growing interest in preserving viable blood cells for future functional studies. The new All of Us Research Program (formerly the Precision Medicine Initiative Cohort Program) biobank plans to house samples from a million or more individuals as part of a cohort with rich phenotypic data and longitudinal follow-up (www.nih.gov/research-training/allofus-research-program). Storage of viable cells for future single-cell analysis offers the promise of new biology, discovery of novel biomarkers, and advances toward the goal of precision medicine. A workshop was held in the summer of 2016 to evaluate the case for preservation of viable mononuclear blood cells and its feasibility within the collection plan for the biobank.
AB - Conventionally, biobanks supporting clinical research studies have preserved serum, plasma, urine, saliva, a variety of tissue types, and stool. With the emergence of increasingly sophisticated technologies for analyzing single cells, there is growing interest in preserving viable blood cells for future functional studies. The new All of Us Research Program (formerly the Precision Medicine Initiative Cohort Program) biobank plans to house samples from a million or more individuals as part of a cohort with rich phenotypic data and longitudinal follow-up (www.nih.gov/research-training/allofus-research-program). Storage of viable cells for future single-cell analysis offers the promise of new biology, discovery of novel biomarkers, and advances toward the goal of precision medicine. A workshop was held in the summer of 2016 to evaluate the case for preservation of viable mononuclear blood cells and its feasibility within the collection plan for the biobank.
KW - biomarkers
KW - cell preservation
KW - cell viability
KW - high-throughput
KW - precision medicine
KW - single-cell analysis
UR - http://www.scopus.com/inward/record.url?scp=85027221276&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85027221276&partnerID=8YFLogxK
U2 - 10.1089/bio.2017.0016
DO - 10.1089/bio.2017.0016
M3 - Article
C2 - 28441039
AN - SCOPUS:85027221276
SN - 1947-5535
VL - 15
SP - 341
EP - 343
JO - Biopreservation and Biobanking
JF - Biopreservation and Biobanking
IS - 4
ER -