TY - JOUR
T1 - HippoBellum
T2 - Acute cerebellar modulation alters hippocampal dynamics and function
AU - Zeidler, Zachary
AU - Hoffmann, Katerina
AU - Krook-Magnuson, Esther
N1 - Publisher Copyright:
Copyright © 2020 the authors
PY - 2020/9/2
Y1 - 2020/9/2
N2 - Here we examine what effects acute manipulation of the cerebellum, a canonically motor structure, can have on the hippocampus, a canonically cognitive structure. In male and female mice, acute perturbation of the cerebellar vermis (lobule 4/5) or simplex produced reliable and specific effects in hippocampal function at cellular, population, and behavioral levels, including evoked local field potentials, increased hippocampal cFos expression, and altered CA1 calcium event rate, amplitudes, and correlated activity. We additionally noted a selective deficit on an object location memory task, which requires objection-location pairing. We therefore combined cerebellar optogenetic stimulation and CA1 calcium imaging with an object-exploration task, and found that cerebellar stimulation reduced the representation of place fields near objects, and prevented a shift in representation to the novel location when an object was moved. Together, these results clearly demonstrate that acute modulation of the cerebellum alters hippocampal function, and further illustrates that the cerebellum can influence cognitive domains.
AB - Here we examine what effects acute manipulation of the cerebellum, a canonically motor structure, can have on the hippocampus, a canonically cognitive structure. In male and female mice, acute perturbation of the cerebellar vermis (lobule 4/5) or simplex produced reliable and specific effects in hippocampal function at cellular, population, and behavioral levels, including evoked local field potentials, increased hippocampal cFos expression, and altered CA1 calcium event rate, amplitudes, and correlated activity. We additionally noted a selective deficit on an object location memory task, which requires objection-location pairing. We therefore combined cerebellar optogenetic stimulation and CA1 calcium imaging with an object-exploration task, and found that cerebellar stimulation reduced the representation of place fields near objects, and prevented a shift in representation to the novel location when an object was moved. Together, these results clearly demonstrate that acute modulation of the cerebellum alters hippocampal function, and further illustrates that the cerebellum can influence cognitive domains.
KW - Cerebellum
KW - Hippocampus
KW - Miniscope
KW - Object memory
KW - Spatial memory
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U2 - 10.1523/JNEUROSCI.0763-20.2020
DO - 10.1523/JNEUROSCI.0763-20.2020
M3 - Article
C2 - 32769107
AN - SCOPUS:85090269816
SN - 0270-6474
VL - 40
SP - 6910
EP - 6926
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 36
ER -