Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

B. K. Tye; P. Sinha; R. Surosky; S. Gibson; G. Maine; S. Eisenberg

doi:10.1007/978-1-4684-5251-8_38

Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

B. K. Tye, P. Sinha, R. Surosky, S. Gibson, G. Maine, S. Eisenberg

Plant and Microbial Biology

Research output: Contribution to journal › Article › peer-review

Abstract

In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

Original language	English (US)
Pages (from-to)	499-510
Number of pages	12
Journal	Basic life sciences
Volume	40
DOIs	https://doi.org/10.1007/978-1-4684-5251-8_38
State	Published - 1986

Access

10.1007/978-1-4684-5251-8_38

OpenUrl availability

Full text

Cite this

@article{e742da9477b5452abda322c3f806f25b,

title = "Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.",

abstract = "In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.",

author = "Tye, {B. K.} and P. Sinha and R. Surosky and S. Gibson and G. Maine and S. Eisenberg",

year = "1986",

doi = "10.1007/978-1-4684-5251-8_38",

language = "English (US)",

volume = "40",

pages = "499--510",

journal = "Basic life sciences",

issn = "0090-5542",

publisher = "Springer GmbH & Co, Auslieferungs-Gesellschaf",

}

TY - JOUR

T1 - Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

AU - Tye, B. K.

AU - Sinha, P.

AU - Surosky, R.

AU - Gibson, S.

AU - Maine, G.

AU - Eisenberg, S.

PY - 1986

Y1 - 1986

N2 - In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

AB - In yeast, the initiation of DNA replication on chromosomes is believed to occur at specific sequences known as autonomously replicating sequences (ARSs). We previously isolated a number of mutants that are defective in the maintenance of minichromosomes. Analysis of these mutants suggests that although ARSs differ greatly from one another in their primary sequences, they appear to share a common enzyme complex for the initiation of DNA replication. However, this initiation enzyme complex probably binds with differential affinity to different ARSs. This idea is corroborated by our identification of an ARS-binding protein that binds to different ARSs with different efficiencies.

UR - http://www.scopus.com/inward/record.url?scp=0022836550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022836550&partnerID=8YFLogxK

U2 - 10.1007/978-1-4684-5251-8_38

DO - 10.1007/978-1-4684-5251-8_38

M3 - Article

C2 - 3551921

AN - SCOPUS:0022836550

SN - 0090-5542

VL - 40

SP - 499

EP - 510

JO - Basic life sciences

JF - Basic life sciences

ER -

Host factors in nuclear plasmid maintenance in Saccharomyces cerevisiae.

Abstract

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this