Abstract
Context: Our previous case-control study identified human neutrophil peptide (HNP) as a potential biomarker for bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. Objective: To prospectively validate HNP as a biomarker for BOS. Materials and methods: HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients. Results: The first HNP measurement after reaching baseline pulmonary function was predictive of developing BOS ≥2 (p=0.0419). HNP remained elevated in those that developed BOS. The effect of potential confounders did not significantly impact BOS-free survival time. Conclusion: HNP levels are elevated early and persistently in those that develop BOS.
Original language | English (US) |
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Pages (from-to) | 663-669 |
Number of pages | 7 |
Journal | Biomarkers |
Volume | 16 |
Issue number | 8 |
DOIs | |
State | Published - Dec 2011 |
Bibliographical note
Funding Information:This work was supported by the National Institutes of Health [Grants HL080041, HL07741] Work performed at the University of Minnesota.
Keywords
- Biomarkers
- Lung transplant
- Rejection