Hyaluronan functions in wound repair that are captured to fuel breast cancer progression

Cornelia Tolg; Britney Jodi Ann Messam; James B. McCarthy; Andrew C. Nelson; Eva Ann Turley

doi:10.3390/biom11111551

Hyaluronan functions in wound repair that are captured to fuel breast cancer progression

Cornelia Tolg, Britney Jodi Ann Messam, James B. McCarthy, Andrew C. Nelson, Eva Ann Turley

Laboratory Medicine and Pathology

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.

Original language	English (US)
Article number	1551
Journal	Biomolecules
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/biom11111551
State	Published - Nov 2021

Bibliographical note

Funding Information:
Andrew C. Nelson: American Cancer Society Clinical Scientist Development Scholar program [132574-CSDG-18-139-01-CSM].

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

Breast cancer
CD44
Hyaluronan
RHAMM
Wound repair

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Hyaluronan functions in wound repair that are captured to fuel breast cancer progression",

abstract = "Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.",

keywords = "Breast cancer, CD44, Hyaluronan, RHAMM, Wound repair",

author = "Cornelia Tolg and Messam, {Britney Jodi Ann} and McCarthy, {James B.} and Nelson, {Andrew C.} and Turley, {Eva Ann}",

note = "Funding Information: Andrew C. Nelson: American Cancer Society Clinical Scientist Development Scholar program [132574-CSDG-18-139-01-CSM]. Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = nov,

doi = "10.3390/biom11111551",

language = "English (US)",

volume = "11",

journal = "Biomolecules",

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T1 - Hyaluronan functions in wound repair that are captured to fuel breast cancer progression

AU - Tolg, Cornelia

AU - Messam, Britney Jodi Ann

AU - McCarthy, James B.

AU - Nelson, Andrew C.

AU - Turley, Eva Ann

N1 - Funding Information: Andrew C. Nelson: American Cancer Society Clinical Scientist Development Scholar program [132574-CSDG-18-139-01-CSM]. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/11

Y1 - 2021/11

N2 - Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.

AB - Signaling from an actively remodeling extracellular matrix (ECM) has emerged as a critical factor in regulating both the repair of tissue injuries and the progression of diseases such as metastatic cancer. Hyaluronan (HA) is a major component of the ECM that normally functions in tissue injury to sequentially promote then suppress inflammation and fibrosis, a duality in which is featured, and regulated in, wound repair. These essential response-to-injury functions of HA in the microenvironment are hijacked by tumor cells for invasion and avoidance of immune detection. In this review, we first discuss the numerous size-dependent functions of HA and emphasize the multifunctional nature of two of its receptors (CD44 and RHAMM) in regulating the signaling duality of HA in excisional wound healing. This is followed by a discussion of how HA metabolism is de-regulated in malignant progression and how targeting HA might be used to better manage breast cancer progression.

KW - Breast cancer

KW - CD44

KW - Hyaluronan

KW - RHAMM

KW - Wound repair

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U2 - 10.3390/biom11111551

DO - 10.3390/biom11111551

M3 - Review article

C2 - 34827550

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SN - 2218-273X

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JO - Biomolecules

JF - Biomolecules

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ER -

Hyaluronan functions in wound repair that are captured to fuel breast cancer progression

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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