Hydrating for resistance to radicicol

Adam S. Duerfeldt; Brian S.J. Blagg

doi:10.1021/cb9000712

Hydrating for resistance to radicicol

Adam S. Duerfeldt, Brian S.J. Blagg

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures, a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about the N-terminal ATP-binding site.

Original language	English (US)
Pages (from-to)	245-247
Number of pages	3
Journal	ACS Chemical Biology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1021/cb9000712
State	Published - Apr 17 2009
Externally published	Yes

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abstract = "Resistance to Hsp90 inhibition has become an important concern as several clinical trials are currently in progress for the treatment of cancer. A summary of known mechanisms of resistance to Hsp90 inhibitors is provided, including the recent solution of the Humicola fuscoatra Hsp90 structure, the organism responsible for the biosynthesis of radicicol. Through careful analyses of Hsp90 structures, a plausible mechanism for resistance to Hsp90 inhibitors has been obtained by single mutations about the N-terminal ATP-binding site.",

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Hydrating for resistance to radicicol

Abstract

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