Abstract
Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white matter content, abnormal synaptogenesis, microgliosis, and functional deficits in the absence of intraventricular hemorrhage. Data suggest that oxidative stress, inflammation, and abnormal substrate metabolism are responsible for these effects.
Original language | English (US) |
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Journal | OBM Neurobiology |
Volume | 3 |
Issue number | 3 |
DOIs | |
State | Published - 2019 |
Bibliographical note
Publisher Copyright:© 2019 by the author.
Keywords
- Cerebral cortex
- Hippocampus
- Hyperglycemia
- Inflammation
- Microglia
- Neurodevelopment
- Oxidative stress
- Prematurity
- Synaptogenesis