Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

Jianxun Lei; Aixiang Jiang; Duanqing Pei

doi:10.1016/S0167-4781(98)00240-1

Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

Jianxun Lei, Aixiang Jiang, Duanqing Pei

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.

Original language	English (US)
Pages (from-to)	400-406
Number of pages	7
Journal	Biochimica et Biophysica Acta - Gene Structure and Expression
Volume	1443
Issue number	3
DOIs	https://doi.org/10.1016/S0167-4781(98)00240-1
State	Published - Dec 22 1998

Bibliographical note

Funding Information:
This work is supported in part by grants (to D.P.) from Arthritis Foundation (MN Chapter), American Cancer Society Institutional Grant, University of Minnesota Graduate School Grant-in-Aid program, Elsa Pardee Foundation, American Heart Association and National Cancer Institute.

Keywords

Angiogenesis
Gene expression
Neovascularization
Splice variant
Vascular endothelial growth factor

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title = "Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183",

abstract = "We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.",

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author = "Jianxun Lei and Aixiang Jiang and Duanqing Pei",

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AU - Lei, Jianxun

AU - Jiang, Aixiang

AU - Pei, Duanqing

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PY - 1998/12/22

Y1 - 1998/12/22

N2 - We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32- kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.

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KW - Angiogenesis

KW - Gene expression

KW - Neovascularization

KW - Splice variant

KW - Vascular endothelial growth factor

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Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183

Abstract

Bibliographical note

Keywords

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