Immunization against the agent of human granulocytic ehrlichiosis in a murine model

Wei Sun; Jacob W. Ijdo; Sam R. Telford; Emir Hodzic; Yan Zhang; Stephen W. Barthold; Erol Fikrig

doi:10.1172/JCI119855

Immunization against the agent of human granulocytic ehrlichiosis in a murine model

Wei Sun, Jacob W. Ijdo, Sam R. Telford, Emir Hodzic, Yan Zhang, Stephen W. Barthold, Erol Fikrig

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67 Scopus citations

Abstract

The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.

Original language	English (US)
Pages (from-to)	3014-3018
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	100
Issue number	12
DOIs	https://doi.org/10.1172/JCI119855
State	Published - Dec 15 1997
Externally published	Yes

Keywords

Antibody
Ehrlichia
Intracellular pathogen
Ticks
Vaccine

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abstract = "The agent of human granulocytic ehrlichiosis (HGE) is a newly recognized tick-borne pathogen that resides within polymorphonuclear leukocytes. C3H/HeN mice can become infected with the agent of HGE (designated aoHGE) by syringe inoculation or tick-borne infection and develop transient neutropenia. They thereby partially mimic human disease and provide a model in which to study immunity to this microorganism. Mice vaccinated with lysates of purified aoHGE, or administered aoHGE antisera, were partially protected from both syringe- and tick-transmitted challenge with aoHGE. These data suggest that antibodies are sufficient to provide substantial, but not complete, immunity against aoHGE.",

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AU - Telford, Sam R.

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AU - Zhang, Yan

AU - Barthold, Stephen W.

AU - Fikrig, Erol

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Immunization against the agent of human granulocytic ehrlichiosis in a murine model

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