Immunovirotherapy for the treatment of glioblastoma

Tooba A. Cheema; Peter E. Fecci; Jianfang Ning; Samuel D. Rabkin

doi:10.4161/onci.27218

Immunovirotherapy for the treatment of glioblastoma

Tooba A. Cheema, Peter E. Fecci, Jianfang Ning, Samuel D. Rabkin

Research output: Contribution to journal › Article › peer-review

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Abstract

We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47Δ-IL12.

Original language	English (US)
Article number	e27218
Journal	OncoImmunology
Volume	3
Issue number	1
DOIs	https://doi.org/10.4161/onci.27218
State	Published - 2014
Externally published	Yes

Keywords

Cancer stem cells
Glioma
Herpes simplex virus
Interleukin-12
Oncolytic virus
Treg

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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AU - Fecci, Peter E.

AU - Ning, Jianfang

AU - Rabkin, Samuel D.

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KW - Glioma

KW - Herpes simplex virus

KW - Interleukin-12

KW - Oncolytic virus

KW - Treg

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Immunovirotherapy for the treatment of glioblastoma

Abstract

Keywords

UN SDGs

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