Impact of diastolic dysfunction on long-term mortality and quality of life after transcatheter aortic valve replacement

Background: There is conflicting data as to whether diastolic dysfunction (DD) affects the prognosis of patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). Methods: Consecutive patients undergoing TAVR underwent assessment of DD with preoperative echocardiography and NT-pro BNP. Long-term survival was ascertained every 6 months by clinic visits or phone. DD was graded according to the new American Society of Echocardiography recommendations. Health status was assessed at baseline and 30 days post-procedure using the KCCQ-12 questionnaire. Long-term survival was displayed using Kaplan–Meier curves according to NT-pro BNP levels and DD grades. Results: We included 222 patients, mean age 78 (±8) years, median STS score 4 (interquartile range = 3–7), median follow-up time 385 days (IQR = 180–640). DD was absent in 25, Grade I in 13, Grade II in 74, Grade III in 24, and indeterminate in 86 patients. Advanced (Grades II–III) DD was associated with higher pre-procedural NT-pro BNP levels (p <.001), worse quality of life (p <.001) but similar surgical risk (p =.43). Advanced and indeterminate DD were associated with increased long-term mortality (25–28% vs. 5%, p =.02) and elevated NT-pro BNP levels (26.4% vs. 9.8%, p =.05). Improvements in quality of life measures were seen in all DD groups (median change in KCCQ score no or Grade I DD:14 [3–21] vs. Grades II–III DD: 15 [16–26; p =.37]). Conclusion: Preoperative NT-pro BNP levels and echocardiographic indices of indeterminate or advanced DD are associated with increased long-term mortality after TAVR but similar improvements in quality of life.