TY - JOUR
T1 - Impaired antibody response rates after high dose short interval hepatitis B virus vaccination of immunosuppressed individuals
AU - Idilman, Ramazan
AU - Colantoni, Alessandra
AU - De Maria, Nicola
AU - Ustun, Celalettin
AU - Sam, Ramin
AU - Ing, Todd S.
AU - Akan, Hamdi
AU - Koc, Haluk
AU - Van Thiel, David H.
PY - 2003/1
Y1 - 2003/1
N2 - Background/Aims: Because a more rapid and high dose vaccination schedule may be advantageous in immunosuppressed individuals to induce an earlier immunization, the aim of the present study was to assess the response to high dose, short interval hepatitis B virus vaccination in various immunosuppressed-patient populations. Methodology: A total of one hundred and thirty-eight immunosuppressed patients (86 cirrhotics, 42 dialysis patients, 10 allogeneic hematopoietic cell transplants) and 26 healthy subjects as controls were vaccinated utilizing a high dose vaccine (40mcg) and a shortened immunization schedule. Results: Ninety-two percent of the controls responded to the high dose, short interval hepatitis B virus vaccination schedule. In contrast, only 48% of the immunosuppressed patients seroconverted to anti-HBs positivity (p<0.001). No difference in the antibody response rate was seen between the various immunosuppressed populations studied. No significant hepatitis B virus vaccination-related adverse effects were seen in any of the groups vaccinated. Conclusions: Although a high dose, short interval hepatitis B virus vaccination schedule is safe in immunosuppressed patients, the antibody response is still significantly reduced as compared to healthy subjects and only slightly greater than that achieved with standard vaccination schedules, as reported in literature. The possibility of achieving an earlier immunization, however, may be of some advantage to protect acquired viral infection.
AB - Background/Aims: Because a more rapid and high dose vaccination schedule may be advantageous in immunosuppressed individuals to induce an earlier immunization, the aim of the present study was to assess the response to high dose, short interval hepatitis B virus vaccination in various immunosuppressed-patient populations. Methodology: A total of one hundred and thirty-eight immunosuppressed patients (86 cirrhotics, 42 dialysis patients, 10 allogeneic hematopoietic cell transplants) and 26 healthy subjects as controls were vaccinated utilizing a high dose vaccine (40mcg) and a shortened immunization schedule. Results: Ninety-two percent of the controls responded to the high dose, short interval hepatitis B virus vaccination schedule. In contrast, only 48% of the immunosuppressed patients seroconverted to anti-HBs positivity (p<0.001). No difference in the antibody response rate was seen between the various immunosuppressed populations studied. No significant hepatitis B virus vaccination-related adverse effects were seen in any of the groups vaccinated. Conclusions: Although a high dose, short interval hepatitis B virus vaccination schedule is safe in immunosuppressed patients, the antibody response is still significantly reduced as compared to healthy subjects and only slightly greater than that achieved with standard vaccination schedules, as reported in literature. The possibility of achieving an earlier immunization, however, may be of some advantage to protect acquired viral infection.
KW - Hepatitis B virus
KW - Immunosuppressed patients
KW - Vaccine
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M3 - Article
C2 - 12630026
AN - SCOPUS:0037270171
SN - 0172-6390
VL - 50
SP - 217
EP - 221
JO - Hepato-Gastroenterology
JF - Hepato-Gastroenterology
IS - 49
ER -