Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review

Joshua D. Newman; Eileen O'Meara; Michael Böhm; Gianluigi Savarese; Patricia R. Kelly; Orly Vardeny; Larry A. Allen; Patrizio Lancellotti; Stephen S. Gottlieb; Zainab Samad; Alanna A. Morris; Nihar R. Desai; Giuseppe M.C. Rosano; John R. Teerlink; Clara Saldarriaga Giraldo; Jo Ann Lindenfeld

doi:10.1016/j.jacc.2023.12.033

Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review

Joshua D. Newman, Eileen O'Meara, Michael Böhm, Gianluigi Savarese, Patricia R. Kelly, Orly Vardeny, Larry A. Allen, Patrizio Lancellotti, Stephen S. Gottlieb, Zainab Samad, Alanna A. Morris, Nihar R. Desai, Giuseppe M.C. Rosano, John R. Teerlink, Clara Saldarriaga Giraldo, Jo Ann Lindenfeld

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Review article › peer-review

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Abstract

Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue owing to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can affect the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with vs without AF.

Original language	English (US)
Pages (from-to)	932-950
Number of pages	19
Journal	Journal of the American College of Cardiology
Volume	83
Issue number	9
DOIs	https://doi.org/10.1016/j.jacc.2023.12.033
State	Published - Mar 5 2024

Bibliographical note

Publisher Copyright:
© 2024 American College of Cardiology Foundation

Keywords

atrial fibrillation
catheter ablation
guideline-directed medical therapy
heart failure

PubMed: MeSH publication types

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Review

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Newman, J. D., O'Meara, E., Böhm, M., Savarese, G., Kelly, P. R., Vardeny, O., Allen, L. A., Lancellotti, P., Gottlieb, S. S., Samad, Z., Morris, A. A., Desai, N. R., Rosano, G. M. C., Teerlink, J. R., Giraldo, C. S., & Lindenfeld, J. A. (2024). Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 83(9), 932-950. https://doi.org/10.1016/j.jacc.2023.12.033

Newman, JD, O'Meara, E, Böhm, M, Savarese, G, Kelly, PR, Vardeny, O, Allen, LA, Lancellotti, P, Gottlieb, SS, Samad, Z, Morris, AA, Desai, NR, Rosano, GMC, Teerlink, JR, Giraldo, CS & Lindenfeld, JA 2024, 'Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review', Journal of the American College of Cardiology, vol. 83, no. 9, pp. 932-950. https://doi.org/10.1016/j.jacc.2023.12.033

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abstract = "Atrial fibrillation (AF) and heart failure (HF) are common cardiovascular conditions that frequently coexist. Among patients with HF, more than one-half also have AF. Both are associated with significant morbidity and mortality. Moreover, the prevalence of each is increasing globally, and this trend is expected to continue owing to an aging population and increased life expectancy. Diagnosis of AF in a patient with HF is associated with greater symptom burden, more frequent hospitalizations, and a worse prognosis. Guideline-directed medical therapy (GDMT) for HF can affect the incidence of AF. Once present, AF can influence the efficacy of some components of GDMT for HF. In this review, we discuss the effect of GDMT for HF across the spectrum of ejection fraction on prevention of AF as well as the benefit of GDMT in patients with vs without AF.",

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Implications of Atrial Fibrillation for Guideline-Directed Therapy in Patients With Heart Failure: JACC State-of-the-Art Review

Abstract

Bibliographical note

Keywords

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