Importance of Clinical Isolates in Cryptococcus neoformans Research

Katrina M. Jackson; Minna Ding; Kirsten Nielsen

doi:10.3390/jof9030364

Importance of Clinical Isolates in Cryptococcus neoformans Research

Katrina M. Jackson, Minna Ding, Kirsten Nielsen

Microbiology

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

The human pathogenic fungus Cryptococcus neoformans is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study C. neoformans, describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host–pathogen interaction during C. neoformans infection.

Original language	English (US)
Article number	364
Journal	Journal of Fungi
Volume	9
Issue number	3
DOIs	https://doi.org/10.3390/jof9030364
State	Published - Mar 2023

Bibliographical note

Funding Information:
Funding was provided by National Institutes of Health grants R01NS10875, R01AI134636, and R21AI150303 to K.N., F31AI148047 to K.M.J., and F30AI155292 to M.D. In addition, M.D. was supported by the University of Minnesota Medical Scientist Training Program (MSTP) under NIH grant T32GM008244.

Publisher Copyright:
© 2023 by the authors.

Keywords

clinical isolates
Cryptococcus neoformans
genotype
host–pathogen interaction

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Review

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title = "Importance of Clinical Isolates in Cryptococcus neoformans Research",

abstract = "The human pathogenic fungus Cryptococcus neoformans is a global health concern. Previous research in the field has focused on studies using reference strains to identify virulence factors, generate mutant libraries, define genomic structures, and perform functional studies. In this review, we discuss the benefits and drawbacks of using reference strains to study C. neoformans, describe how the study of clinical isolates has expanded our understanding of pathogenesis, and highlight how studies using clinical isolates can further develop our understanding of the host–pathogen interaction during C. neoformans infection.",

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Importance of Clinical Isolates in Cryptococcus neoformans Research

Abstract

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