Abstract
Infusion of prostaglandin (PG) E1 in anesthetized dogs significantly lowered circulating insulin levels and inhibited insulin responses following intravenous glucose. A similar trend was observed with PGE2. Alpha adrenergic blockade did not reverse the PGE1 effect. Epinephrine infusion also inhibited glucose-stimulated insulin secretion, an effect that was not reversed by indomethacin. Therefore, in this investigative model, PGE1 inhibited insulin secretion but no interdependency of PGE1 and alpha adrenergic effects were found.
Original language | English (US) |
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Pages (from-to) | 501-508 |
Number of pages | 8 |
Journal | Prostaglandins |
Volume | 6 |
Issue number | 6 |
DOIs | |
State | Published - Jun 25 1974 |
Externally published | Yes |
Bibliographical note
Funding Information:This work was presented in part at the Prostaglandin Conference at Stratton Mountain, Vermont, March 12, 1974, and was supported by the Veterans Administration Research and Education Program.