In vivo proton magnetic resonance spectroscopy of breast cancer: A review of the literature

Jonathan K.P. Begley; Thomas W. Redpath; Patrick J. Bolan; Fiona J. Gilbert

doi:10.1186/bcr3132

In vivo proton magnetic resonance spectroscopy of breast cancer: A review of the literature

Jonathan K.P. Begley, Thomas W. Redpath, Patrick J. Bolan, Fiona J. Gilbert

Center for Magnetic Resonance Research

Research output: Contribution to journal › Review article › peer-review

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Abstract

An emerging clinical modality called proton magnetic resonance spectroscopy ( ¹H-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with ¹H-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. ¹H-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast ¹H-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of ¹H-MRS for breast cancer.

Original language	English (US)
Article number	207
Journal	Breast Cancer Research
Volume	14
Issue number	2
DOIs	https://doi.org/10.1186/bcr3132
State	Published - Apr 19 2012

Bibliographical note

Funding Information:
Dr Bolan wishes to acknowledge support from the NIH for the P41-RR008079 grant.

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title = "In vivo proton magnetic resonance spectroscopy of breast cancer: A review of the literature",

abstract = "An emerging clinical modality called proton magnetic resonance spectroscopy ( 1H-MRS) enables the non-invasive in vivo assessment of tissue metabolism and is demonstrating applications in improving the specificity of MR breast lesion diagnosis and monitoring tumour responsiveness to neoadjuvant chemotherapies. Variations in the concentration of choline-based cellular metabolites, detectable with 1H-MRS, have shown an association with malignant transformation of tissue in in vivo and in vitro studies. 1H-MRS exists as an adjunct to the current routine clinical breast MR examination. This review serves as an introduction to the field of breast 1H-MRS, discusses modern high-field strength and quantitative approaches and technical considerations, and reviews the literature with respect to the application of 1H-MRS for breast cancer.",

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AU - Bolan, Patrick J.

AU - Gilbert, Fiona J.

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In vivo proton magnetic resonance spectroscopy of breast cancer: A review of the literature

Abstract

Bibliographical note

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