TY - JOUR
T1 - Increased risk of temporomandibular joint closed lock
T2 - A case-control study of ANKH polymorphisms
AU - Huang, Boyen
AU - Takahashi, Katsu
AU - Sakata, Tomoko
AU - Kiso, Honoka
AU - Sugai, Manabu
AU - Fujimura, Kazuma
AU - Shimizu, Akira
AU - Kosugi, Shinji
AU - Sato, Tosiya
AU - Bessho, Kazuhisa
PY - 2011/10/7
Y1 - 2011/10/7
N2 - Objectives: This study aimed to carry out a histological examination of the temporomandibular joint (TMJ) in ank mutant mice and to identify polymorphisms of the human ANKH gene in order to establish the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms. Materials and Methods: Specimens from the TMJ of ank mutant and wild-type mice were inspected with a haematoxylin and eosin staining method. A sample of 55 TMD patients were selected. Each was examined with standard clinical procedures and genotyping techniques. Results: The major histological finding in ank mutant mice was joint space narrowing. Within TMD patients, closed lock was more prevalent among ANKH-OR homozygotes (p = 0.011, OR = 7.7, 95% CI 1.6-36.5) and the elder (p = 0.005, OR = 2.4, 95% CI 1.3-4.3). Conclusions: Fibrous ankylosis was identified in the TMJ of ank mutant mice. In the human sample, ANKH-OR polymorphism was found to be a genetic marker associated with TMJ closed lock. Future investigations correlating genetic polymorphism to TMD are indicated.
AB - Objectives: This study aimed to carry out a histological examination of the temporomandibular joint (TMJ) in ank mutant mice and to identify polymorphisms of the human ANKH gene in order to establish the relationship between the type of temporomandibular disorders (TMD) and ANKH polymorphisms. Materials and Methods: Specimens from the TMJ of ank mutant and wild-type mice were inspected with a haematoxylin and eosin staining method. A sample of 55 TMD patients were selected. Each was examined with standard clinical procedures and genotyping techniques. Results: The major histological finding in ank mutant mice was joint space narrowing. Within TMD patients, closed lock was more prevalent among ANKH-OR homozygotes (p = 0.011, OR = 7.7, 95% CI 1.6-36.5) and the elder (p = 0.005, OR = 2.4, 95% CI 1.3-4.3). Conclusions: Fibrous ankylosis was identified in the TMJ of ank mutant mice. In the human sample, ANKH-OR polymorphism was found to be a genetic marker associated with TMJ closed lock. Future investigations correlating genetic polymorphism to TMD are indicated.
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U2 - 10.1371/journal.pone.0025503
DO - 10.1371/journal.pone.0025503
M3 - Article
C2 - 22003394
AN - SCOPUS:80053911246
SN - 1932-6203
VL - 6
JO - PloS one
JF - PloS one
IS - 10
M1 - e25503
ER -