Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes

Sasha Z. Prisco; Felipe Kazmirczak; Thenappan Thenappan; Kurt W. Prins

doi:10.1002/pul2.12011

Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes

Sasha Z. Prisco, Felipe Kazmirczak, Thenappan Thenappan, Kurt W. Prins

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Pharmaceuticals for left ventricular (LV) dysfunction do not have similar success in right ventricular (RV) failure, which may reflect biological differences between the ventricles. In this study, we performed Ingenuity Pathway Analysis of the Human Cell Atlas to understand how the transcriptomic signatures of the RV and LV differ.

Original language	English (US)
Article number	e12011
Journal	Pulmonary Circulation
Volume	12
Issue number	1
DOIs	https://doi.org/10.1002/pul2.12011
State	Published - Jan 2022

Bibliographical note

Funding Information:
Sasha Z. Prisco is funded by NIH F32 HL154533, NIH T32 HL144472, a University of Minnesota Clinical and Translational Science award (NIH UL1 TR002494), and a University of Minnesota Medical School Academic Investment Educational Program grant. Thenappan Thenappan is funded by the Cardiovascular Medical Research and Education Fund and the University of Minnesota Futures Grant. Kurt W. Prins is funded by NIH K08 HL140100, the Jenesis Award from United Therapeutics, a Lillehei Heart Institute Cardiovascular Seed Grant, the University of Minnesota Futures Grant, the University of Minnesota Faculty Research Development Grant Program, the Cardiovascular Medical Research and Education Fund, and an American Lung Association Innovative Award IA‐816386. The content is solely the responsibility of the authors and does not represent the official views of the NIH or any other funding sources.

Publisher Copyright:
© 2021 The Authors. Pulmonary Circulation published by Wiley Periodicals LLC on behalf of the Pulmonary Vascular Research Institute.

Keywords

heart diseases
pulmonary heart disease
right ventricle function and dysfunction

PubMed: MeSH publication types

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Ingenuity pathway analysis of the human cardiac cell Atlas identifies differences between right and left ventricular cardiomyocytes

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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