Inhibition of Mitochondrial Antioxidant Defense and CDK4/6 in Mesothelioma

Marian Kratzke, George Scaria, Stephen Porter, Betsy Kren, Mark A. Klein

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Advanced mesothelioma is considered an incurable disease and new treatment strategies are needed. Previous studies have demonstrated that mitochondrial antioxidant defense proteins and the cell cycle may contribute to mesothelioma growth, and that the inhibition of these pathways may be effective against this cancer. We demonstrated that the antioxidant defense inhibitor auranofin and the cyclin-dependent kinase 4/6 inhibitor palbociclib could decrease mesothelioma cell proliferation alone or in combination. In addition, we determined the effects of these compounds on colony growth, cell cycle progression, and the expression of key antioxidant defense and cell cycle proteins. Auranofin and palbociclib were effective in decreasing cell growth and inhibiting the above-described activity across all assays. Further study of this drug combination will elucidate the contribution of these pathways to mesothelioma activity and may reveal a new treatment strategy.

Original languageEnglish (US)
Article number4380
JournalMolecules
Volume28
Issue number11
DOIs
StatePublished - Jun 2023

Bibliographical note

Publisher Copyright:
© 2023 by the authors.

Keywords

  • antioxidant
  • cell cycle
  • cyclin
  • cyclin-dependent kinase
  • mesothelioma
  • mitochondria

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