Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid

Jeffrey A. Pfefferkorn; Richard Nugent; Rebecca J. Gross; Meredith Greene; Mark A. Mitchell; Matthew T. Reding; Lee A. Funk; Rebecca Anderson; Peter A. Wells; John A. Shelly; Robert Anstadt; Barry C. Finzel; Melissa S. Harris; Robert E. Kilkuskie; Laurice A. Kopta; Francis J. Schwende

doi:10.1016/j.bmcl.2005.03.106

Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid

Jeffrey A. Pfefferkorn, Richard Nugent, Rebecca J. Gross, Meredith Greene, Mark A. Mitchell, Matthew T. Reding, Lee A. Funk, Rebecca Anderson, Peter A. Wells, John A. Shelly, Robert Anstadt, Barry C. Finzel, Melissa S. Harris, Robert E. Kilkuskie, Laurice A. Kopta, Francis J. Schwende

Medicinal Chemistry

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Abstract

A novel series of non-nucleoside HCV NS5B polymerase inhibitors was prepared from a (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid template. Solution and solid phase analog synthesis focused on the northern region of the template combined with structure based design led to the discovery of several potent and orally bioavailable lead compounds.

Original language	English (US)
Pages (from-to)	2812-2818
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	11
DOIs	https://doi.org/10.1016/j.bmcl.2005.03.106
State	Published - Jun 2 2005

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Pfefferkorn, J. A., Nugent, R., Gross, R. J., Greene, M., Mitchell, M. A., Reding, M. T., Funk, L. A., Anderson, R., Wells, P. A., Shelly, J. A., Anstadt, R., Finzel, B. C., Harris, M. S., Kilkuskie, R. E., Kopta, L. A., & Schwende, F. J. (2005). Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid. Bioorganic and Medicinal Chemistry Letters, 15(11), 2812-2818. https://doi.org/10.1016/j.bmcl.2005.03.106

Pfefferkorn, JA, Nugent, R, Gross, RJ, Greene, M, Mitchell, MA, Reding, MT, Funk, LA, Anderson, R, Wells, PA, Shelly, JA, Anstadt, R, Finzel, BC, Harris, MS, Kilkuskie, RE, Kopta, LA & Schwende, FJ 2005, 'Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 11, pp. 2812-2818. https://doi.org/10.1016/j.bmcl.2005.03.106

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Inhibitors of HCV NS5B polymerase. Part 2: Evaluation of the northern region of (2Z)-2-benzoylamino-3-(4-phenoxy-phenyl)-acrylic acid

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