Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer

Deepali Sachdev; Douglas Yee

doi:10.1007/s10911-006-9010-8

Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer

Deepali Sachdev, Douglas Yee

Medicine - Hematology, Oncology, Transplant

Research output: Contribution to journal › Review article › peer-review

52 Scopus citations

Abstract

The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.

Original language	English (US)
Pages (from-to)	27-39
Number of pages	13
Journal	Journal of mammary gland biology and neoplasia
Volume	11
Issue number	1
DOIs	https://doi.org/10.1007/s10911-006-9010-8
State	Published - Jan 2006

Keywords

Antibodies
Breast cancer
Insulin-like growth factors
Small molecule inhibitors
Targeted therapy
TypeI IGF receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10911-006-9010-8

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KW - Targeted therapy

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Inhibitors of insulin-like growth factor signaling: A therapeutic approach for breast cancer

Abstract

Keywords

UN SDGs

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