Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

Deanna J. Greene; Scott Marek; Evan M. Gordon; Joshua S. Siegel; Caterina Gratton; Timothy O. Laumann; Adrian W. Gilmore; Jeffrey J. Berg; Annie L. Nguyen; Donna Dierker; Andrew N. Van; Mario Ortega; Dillan J. Newbold; Jacqueline M. Hampton; Ashley N. Nielsen; Kathleen B. McDermott; Jarod L. Roland; Scott A. Norris; Steven M. Nelson; Abraham Z. Snyder; Bradley L. Schlaggar; Steven E. Petersen; Nico U.F. Dosenbach

doi:10.1016/j.neuron.2019.11.012

Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

Deanna J. Greene, Scott Marek, Evan M. Gordon, Joshua S. Siegel, Caterina Gratton, Timothy O. Laumann, Adrian W. Gilmore, Jeffrey J. Berg, Annie L. Nguyen, Donna Dierker, Andrew N. Van, Mario Ortega, Dillan J. Newbold, Jacqueline M. Hampton, Ashley N. Nielsen, Kathleen B. McDermott, Jarod L. Roland, Scott A. Norris, Steven M. Nelson, Abraham Z. SnyderBradley L. Schlaggar, Steven E. Petersen, Nico U.F. Dosenbach

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

Individual functional mapping of the human subcortex revealed network integration zones (motor, cognitive, visual attention) that were variable and consistent across people. These individualized maps of cortico-subcortical circuits may have immediate clinical translation for invasive personalized treatments (e.g., deep brain stimulation).

Original language	English (US)
Pages (from-to)	742-758.e6
Journal	Neuron
Volume	105
Issue number	4
DOIs	https://doi.org/10.1016/j.neuron.2019.11.012
State	Published - Feb 19 2020
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by NIH grants K01 MH104592 (to D.J.G.), T32 MH100019 (to S.M.), K23 NS088590 (to N.U.F.D.), F30 MH100872 (to T.O.L.), R25 MH112473 (to T.O.L.), F31 NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54 HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G., N.U.F.D., and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D., B.L.S., and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government.

Funding Information:
This work was supported by NIH grants K01MH104592 (to D.J.G.), T32MH100019 (to S.M.), K23NS088590 (to N.U.F.D.), F30MH100872 (to T.O.L.), R25MH112473 (to T.O.L.), F31NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G. N.U.F.D. and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D. B.L.S. and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. Conceptualization, D.J.G. S.M. E.M.G. J.S.S. J.L.R. S.A.N. and N.U.F.D.; Methodology, Software, and Formal Analysis, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. D.D. A.N.V. M.O. D.J.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Investigation, Resources, and Data Curation, D.J.G. M.O. T.O.L. A.W.G. J.J.B. A.L.N. D.J.N. J.M.H. A.N.N. K.B.M. S.M.N. and N.U.F.D.; Writing ? Original Draft, D.J.G. S.M. S.A.N. and N.U.F.D.; Writing ? Review & Editing, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. A.W.G. J.J.B. A.L.N. D.D. A.N.V. M.O. D.J.N. J.M.H. A.N.N. K.B.M. J.L.R. S.A.N. S.M.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Supervision, D.J.G. and N.U.F.D. The authors declare no competing interests.

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

basal ganglia
brain networks
deep brain stimulation
functional connectivity
precision functional mapping
resting state
subcortex
thalamus

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10.1016/j.neuron.2019.11.012

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Cite this

Greene, D. J., Marek, S., Gordon, E. M., Siegel, J. S., Gratton, C., Laumann, T. O., Gilmore, A. W., Berg, J. J., Nguyen, A. L., Dierker, D., Van, A. N., Ortega, M., Newbold, D. J., Hampton, J. M., Nielsen, A. N., McDermott, K. B., Roland, J. L., Norris, S. A., Nelson, S. M., ... Dosenbach, N. U. F. (2020). Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals. Neuron, 105(4), 742-758.e6. https://doi.org/10.1016/j.neuron.2019.11.012

Greene, DJ, Marek, S, Gordon, EM, Siegel, JS, Gratton, C, Laumann, TO, Gilmore, AW, Berg, JJ, Nguyen, AL, Dierker, D, Van, AN, Ortega, M, Newbold, DJ, Hampton, JM, Nielsen, AN, McDermott, KB, Roland, JL, Norris, SA, Nelson, SM, Snyder, AZ, Schlaggar, BL, Petersen, SE & Dosenbach, NUF 2020, 'Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals', Neuron, vol. 105, no. 4, pp. 742-758.e6. https://doi.org/10.1016/j.neuron.2019.11.012

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title = "Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals",

abstract = "Individual functional mapping of the human subcortex revealed network integration zones (motor, cognitive, visual attention) that were variable and consistent across people. These individualized maps of cortico-subcortical circuits may have immediate clinical translation for invasive personalized treatments (e.g., deep brain stimulation).",

keywords = "basal ganglia, brain networks, deep brain stimulation, functional connectivity, precision functional mapping, resting state, subcortex, thalamus",

author = "Greene, {Deanna J.} and Scott Marek and Gordon, {Evan M.} and Siegel, {Joshua S.} and Caterina Gratton and Laumann, {Timothy O.} and Gilmore, {Adrian W.} and Berg, {Jeffrey J.} and Nguyen, {Annie L.} and Donna Dierker and Van, {Andrew N.} and Mario Ortega and Newbold, {Dillan J.} and Hampton, {Jacqueline M.} and Nielsen, {Ashley N.} and McDermott, {Kathleen B.} and Roland, {Jarod L.} and Norris, {Scott A.} and Nelson, {Steven M.} and Snyder, {Abraham Z.} and Schlaggar, {Bradley L.} and Petersen, {Steven E.} and Dosenbach, {Nico U.F.}",

note = "Funding Information: This work was supported by NIH grants K01 MH104592 (to D.J.G.), T32 MH100019 (to S.M.), K23 NS088590 (to N.U.F.D.), F30 MH100872 (to T.O.L.), R25 MH112473 (to T.O.L.), F31 NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54 HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G., N.U.F.D., and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D., B.L.S., and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. Funding Information: This work was supported by NIH grants K01MH104592 (to D.J.G.), T32MH100019 (to S.M.), K23NS088590 (to N.U.F.D.), F30MH100872 (to T.O.L.), R25MH112473 (to T.O.L.), F31NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G. N.U.F.D. and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D. B.L.S. and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. Conceptualization, D.J.G. S.M. E.M.G. J.S.S. J.L.R. S.A.N. and N.U.F.D.; Methodology, Software, and Formal Analysis, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. D.D. A.N.V. M.O. D.J.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Investigation, Resources, and Data Curation, D.J.G. M.O. T.O.L. A.W.G. J.J.B. A.L.N. D.J.N. J.M.H. A.N.N. K.B.M. S.M.N. and N.U.F.D.; Writing ? Original Draft, D.J.G. S.M. S.A.N. and N.U.F.D.; Writing ? Review & Editing, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. A.W.G. J.J.B. A.L.N. D.D. A.N.V. M.O. D.J.N. J.M.H. A.N.N. K.B.M. J.L.R. S.A.N. S.M.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Supervision, D.J.G. and N.U.F.D. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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doi = "10.1016/j.neuron.2019.11.012",

language = "English (US)",

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T1 - Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

AU - Greene, Deanna J.

AU - Marek, Scott

AU - Gordon, Evan M.

AU - Siegel, Joshua S.

AU - Gratton, Caterina

AU - Laumann, Timothy O.

AU - Gilmore, Adrian W.

AU - Berg, Jeffrey J.

AU - Nguyen, Annie L.

AU - Dierker, Donna

AU - Van, Andrew N.

AU - Ortega, Mario

AU - Newbold, Dillan J.

AU - Hampton, Jacqueline M.

AU - Nielsen, Ashley N.

AU - McDermott, Kathleen B.

AU - Roland, Jarod L.

AU - Norris, Scott A.

AU - Nelson, Steven M.

AU - Snyder, Abraham Z.

AU - Schlaggar, Bradley L.

AU - Petersen, Steven E.

AU - Dosenbach, Nico U.F.

N1 - Funding Information: This work was supported by NIH grants K01 MH104592 (to D.J.G.), T32 MH100019 (to S.M.), K23 NS088590 (to N.U.F.D.), F30 MH100872 (to T.O.L.), R25 MH112473 (to T.O.L.), F31 NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54 HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G., N.U.F.D., and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D., B.L.S., and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. Funding Information: This work was supported by NIH grants K01MH104592 (to D.J.G.), T32MH100019 (to S.M.), K23NS088590 (to N.U.F.D.), F30MH100872 (to T.O.L.), R25MH112473 (to T.O.L.), F31NS110332 (to D.J.N.), P30NS098577 (to N.I.A.C.), and U54HD087011 (to IDDRC at WU); Jacobs Foundation grant 2016121703 (N.U.F.D.); the Child Neurology Foundation (to N.U.F.D.); the McDonnell Center for Systems Neuroscience (to D.J.G. N.U.F.D. and B.L.S.); the Hope Center for Neurological Disorders (to N.U.F.D. B.L.S. and S.E.P.); and US Department of Veterans Affairs Clinical Sciences Research and Development Service grant 1IK2CX001680 (to E.M.G.). The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the US government. Conceptualization, D.J.G. S.M. E.M.G. J.S.S. J.L.R. S.A.N. and N.U.F.D.; Methodology, Software, and Formal Analysis, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. D.D. A.N.V. M.O. D.J.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Investigation, Resources, and Data Curation, D.J.G. M.O. T.O.L. A.W.G. J.J.B. A.L.N. D.J.N. J.M.H. A.N.N. K.B.M. S.M.N. and N.U.F.D.; Writing ? Original Draft, D.J.G. S.M. S.A.N. and N.U.F.D.; Writing ? Review & Editing, D.J.G. S.M. E.M.G. J.S.S. C.G. T.O.L. A.W.G. J.J.B. A.L.N. D.D. A.N.V. M.O. D.J.N. J.M.H. A.N.N. K.B.M. J.L.R. S.A.N. S.M.N. A.Z.S. B.L.S. S.E.P. and N.U.F.D.; Supervision, D.J.G. and N.U.F.D. The authors declare no competing interests. Publisher Copyright: © 2019 Elsevier Inc.

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KW - brain networks

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KW - precision functional mapping

KW - resting state

KW - subcortex

KW - thalamus

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Integrative and Network-Specific Connectivity of the Basal Ganglia and Thalamus Defined in Individuals

Abstract

Bibliographical note

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