TY - JOUR
T1 - Interspecies Organogenesis for Human Transplantation
AU - Crane, Andrew T.
AU - Aravalli, Rajagopal N.
AU - Asakura, Atsushi
AU - Grande, Andrew W.
AU - Krishna, Venkatramana D.
AU - Carlson, Daniel F.
AU - Cheeran, Maxim C.J.
AU - Danczyk, Georgette
AU - Dutton, James R.
AU - Hackett, Perry B.
AU - Hu, Wei Shou
AU - Li, Ling
AU - Lu, Wei Cheng
AU - Miller, Zachary D.
AU - O’Brien, Timothy D.
AU - Panoskaltsis-Mortari, Angela
AU - Parr, Ann M.
AU - Pearce, Clairice
AU - Ruiz-Estevez, Mercedes
AU - Shiao, Maple
AU - Sipe, Christopher J.
AU - Toman, Nikolas G.
AU - Voth, Joseph
AU - Xie, Hui
AU - Steer, Clifford J.
AU - Low, Walter C.
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2019/9/1
Y1 - 2019/9/1
N2 - Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.
AB - Blastocyst complementation combined with gene editing is an emerging approach in the field of regenerative medicine that could potentially solve the worldwide problem of organ shortages for transplantation. In theory, blastocyst complementation can generate fully functional human organs or tissues, grown within genetically engineered livestock animals. Targeted deletion of a specific gene(s) using gene editing to cause deficiencies in organ development can open a niche for human stem cells to occupy, thus generating human tissues. Within this review, we will focus on the pancreas, liver, heart, kidney, lung, and skeletal muscle, as well as cells of the immune and nervous systems. Within each of these organ systems, we identify and discuss (i) the common causes of organ failure; (ii) the current state of regenerative therapies; and (iii) the candidate genes to knockout and enable specific exogenous organ development via the use of blastocyst complementation. We also highlight some of the current barriers limiting the success of blastocyst complementation.
KW - blastocyst complementation
KW - development
KW - gene editing
KW - organ bioengineering
KW - transplantation
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U2 - 10.1177/0963689719845351
DO - 10.1177/0963689719845351
M3 - Review article
C2 - 31426664
AN - SCOPUS:85072716989
SN - 0963-6897
VL - 28
SP - 1091
EP - 1105
JO - Cell transplantation
JF - Cell transplantation
IS - 9-10
ER -