Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

Emily A. Thompson; Jason S. Mitchell; Lalit K. Beura; David J. Torres; Paulus Mrass; Mark J. Pierson; Judy L. Cannon; David Masopust; Brian T. Fife; Vaiva Vezys

doi:10.1016/j.celrep.2019.02.034

Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

Emily A. Thompson, Jason S. Mitchell, Lalit K. Beura, David J. Torres, Paulus Mrass, Mark J. Pierson, Judy L. Cannon, David Masopust, Brian T. Fife, Vaiva Vezys

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17 Scopus citations

Abstract

Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.

Original language	English (US)
Pages (from-to)	2859-2867.e4
Journal	Cell reports
Volume	26
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.02.034
State	Published - Mar 12 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s)

Keywords

2-photon microscopy
CD8 T cells
T cell migration
immune surveillance
integrins
mathematical modeling
motility
mucosal immunity
resident memory T cells
tolerance

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title = "Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues",

abstract = "Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.",

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AU - Mitchell, Jason S.

AU - Beura, Lalit K.

AU - Torres, David J.

AU - Mrass, Paulus

AU - Pierson, Mark J.

AU - Cannon, Judy L.

AU - Masopust, David

AU - Fife, Brian T.

AU - Vezys, Vaiva

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AB - Using in vivo imaging of pathogen- and self-specific CD8 T cells in the small intestine, Thompson et al. reveal dynamic changes in the speed and volume of tissue surveyed by CD8 T cells over time after antigen encounter. Migration was CD103 independent, and motility was most limited during the memory response.

KW - 2-photon microscopy

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KW - T cell migration

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KW - integrins

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KW - resident memory T cells

KW - tolerance

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Interstitial Migration of CD8αβ T Cells in the Small Intestine Is Dynamic and Is Dictated by Environmental Cues

Abstract

Bibliographical note

Keywords

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