Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats

Chilivery Ravi Kiran; Chandrasekaran Rajkuberan; Alagar Yadav Sangilimuthu; Faruck L. Hakkim; Hamid Bakshi; Sowmya Priya Manoharan

doi:10.1080/10496475.2021.1891181

Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats

Chilivery Ravi Kiran, Chandrasekaran Rajkuberan, Alagar Yadav Sangilimuthu, Faruck L. Hakkim, Hamid Bakshi, Sowmya Priya Manoharan

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The calcium oxalate reduction capacity of Argemone mexicana was demonstrated in vivo in ethylene glycol-induced urolithic rats. A. mexicana leaves extract at 400 and 750 mg kg⁻¹ b.w. demonstrated protection of renal tubes, kidney cells and reduced the levels of serum creatinine and calcium compared to the urolithiasis induced group. Further, A. mexicana restored blood and urine markers to normal before and after treatment in urolithiasis rats and caused the breakdown of calcium oxalate crystals in the urinary tract as observed by microscopy. The A. mexicana extract protected from renal damage and repaired and increased diuresis activity thereby completely excreted calcium oxalate crystals in renal tubes. Analysis of methanolic extract of A. mexicana showed the presence of a 3,4-dihydro-3-hydroxy-7-(7-methyloctyl)naphthalen-2(1 H)-one as the bioactive compound which may be attributed to the antiurolithiatic activity.

Original language	English (US)
Pages (from-to)	289-304
Number of pages	16
Journal	Journal of Herbs, Spices and Medicinal Plants
Volume	27
Issue number	3
DOIs	https://doi.org/10.1080/10496475.2021.1891181
State	Published - 2021
Externally published	Yes

Bibliographical note

Funding Information:
Department of Science and Technology-FIST, New Delhi vide File No. SR/FST/LS-1/2018/187.

Publisher Copyright:
© 2021 Taylor & Francis Group, LLC.

Keywords

NMR spectroscopy
Urolithiasis
calcium oxalate
column chromatography
creatinine

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title = "Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats",

abstract = "The calcium oxalate reduction capacity of Argemone mexicana was demonstrated in vivo in ethylene glycol-induced urolithic rats. A. mexicana leaves extract at 400 and 750 mg kg−1 b.w. demonstrated protection of renal tubes, kidney cells and reduced the levels of serum creatinine and calcium compared to the urolithiasis induced group. Further, A. mexicana restored blood and urine markers to normal before and after treatment in urolithiasis rats and caused the breakdown of calcium oxalate crystals in the urinary tract as observed by microscopy. The A. mexicana extract protected from renal damage and repaired and increased diuresis activity thereby completely excreted calcium oxalate crystals in renal tubes. Analysis of methanolic extract of A. mexicana showed the presence of a 3,4-dihydro-3-hydroxy-7-(7-methyloctyl)naphthalen-2(1 H)-one as the bioactive compound which may be attributed to the antiurolithiatic activity.",

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AU - Rajkuberan, Chandrasekaran

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AU - Hakkim, Faruck L.

AU - Bakshi, Hamid

AU - Manoharan, Sowmya Priya

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AB - The calcium oxalate reduction capacity of Argemone mexicana was demonstrated in vivo in ethylene glycol-induced urolithic rats. A. mexicana leaves extract at 400 and 750 mg kg−1 b.w. demonstrated protection of renal tubes, kidney cells and reduced the levels of serum creatinine and calcium compared to the urolithiasis induced group. Further, A. mexicana restored blood and urine markers to normal before and after treatment in urolithiasis rats and caused the breakdown of calcium oxalate crystals in the urinary tract as observed by microscopy. The A. mexicana extract protected from renal damage and repaired and increased diuresis activity thereby completely excreted calcium oxalate crystals in renal tubes. Analysis of methanolic extract of A. mexicana showed the presence of a 3,4-dihydro-3-hydroxy-7-(7-methyloctyl)naphthalen-2(1 H)-one as the bioactive compound which may be attributed to the antiurolithiatic activity.

KW - NMR spectroscopy

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KW - column chromatography

KW - creatinine

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Intrinsic Evaluation of Antiurolithiatic Capacity of Argemone mexicana L. in Wistar Albino Rats

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Keywords

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