Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

Satagopan Uthra; Rajiv Raman; Bickol N. Mukesh; Kumari R. Padmaja; Pradeep G. Paul; Praveena Lakshmipathy; Perumal Gnanamoorthy; Tarun Sharma; Catherine A. McCarty; Govindasamy Kumaramanickavel

doi:10.1080/13816810701209669

Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

Satagopan Uthra, Rajiv Raman, Bickol N. Mukesh, Kumari R. Padmaja, Pradeep G. Paul, Praveena Lakshmipathy, Perumal Gnanamoorthy, Tarun Sharma, Catherine A. McCarty, Govindasamy Kumaramanickavel

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31 Scopus citations

Abstract

A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

Original language	English (US)
Pages (from-to)	77-81
Number of pages	5
Journal	Ophthalmic Genetics
Volume	28
Issue number	2
DOIs	https://doi.org/10.1080/13816810701209669
State	Published - Apr 2007

Bibliographical note

Funding Information:
We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.

Keywords

Diabetic retinopathy
Hypoxia
Intronic VNTR
Type 2 diabetes
eNOS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India",

abstract = "A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.",

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note = "Funding Information: We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.",

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AU - Uthra, Satagopan

AU - Raman, Rajiv

AU - Mukesh, Bickol N.

AU - Padmaja, Kumari R.

AU - Paul, Pradeep G.

AU - Lakshmipathy, Praveena

AU - Gnanamoorthy, Perumal

AU - Sharma, Tarun

AU - McCarty, Catherine A.

AU - Kumaramanickavel, Govindasamy

N1 - Funding Information: We thank RD TATA Trust, Mumbai, India, for the financial grant and patients who participated in the study. We are very thankful to the Sankara Nethralaya Diabetic retinopathy project team for collecting the patients.

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N2 - A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

AB - A 27-bp variable number tandem repeat (VNTR) in intron 4 of endothelial nitric oxide synthase (eNOS) gene has been associated with the risk for developing diabetic retinopathy (DR) in various ethnic populations. Hundred and eighty seven patients with retinopathy (cases; DR+) and 188 patients without retinopathy (controls: DR-) from southern India who had type 2 diabetes mellitus (T2DM) for more than 10 years, were included in the study. We could neither find significant allelic association with clinical severity of DR nor with macular edema. Our results suggest lack of association of intron 4 VNTR of eNOS gene with DR in southern India.

KW - Diabetic retinopathy

KW - Hypoxia

KW - Intronic VNTR

KW - Type 2 diabetes

KW - eNOS

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Intron 4 VNTR of endothelial nitric oxide synthase (eNOS) gene and diabetic retinopathy in type 2 patients in southern India

Abstract

Bibliographical note

Keywords

UN SDGs

Access

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