Investigation of 2′-Deoxyadenosine-Derived Adducts Specifically Formed in Rat Liver and Lung DNA by N′-Nitrosonornicotine Metabolism

Medicine & Life Sciences

• N'-nitrosonornicotine 100%
• 2'-deoxyadenosine 84%
• Nitrosamines 77%
• 2'-deoxynebularine 51%
• Hydroxylation 35%
• DNA 31%
• Lung 30%
• Liver 29%
• DNA Adducts 19%
• pyridine 13%
• 5'-acetoxy-N'-nitrosonornicotine 13%
• deoxyinosine 9%
• Erythrocebus patas 9%
• tetrahydrofuran 8%
• 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 7%
• calf thymus DNA 7%
• International Agencies 7%
• Metabolic Activation 6%
• Tandem Mass Spectrometry 5%
• Liquid Chromatography 5%
• Metabolic Networks and Pathways 5%
• Drinking Water 5%
• Cytochrome P-450 Enzyme System 5%
• Tobacco 4%
• Biomarkers 3%
• In Vitro Techniques 2%
• Neoplasms 1%

Chemical Compounds

• Nitrosamine 74%
• Pharmacological Metabolism 43%
• Adduct 40%
• Metabolic Activation 6%
• Carcinogenic 5%
• Drinking Water 5%
• NMR Data 5%
• Reduction 4%
• Biological Marker 4%
• Cytochrome 4%
• Tandem Mass Spectrometry 4%
• Metabolic 4%
• Liquid 2%