IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials

Karen M. Chisholm; Jeffrey Mohlman; Michael Liew; Amanda Termuhlen; Mitchell S. Cairo; Thomas G. Gross; Sherrie L. Perkins; Rodney R. Miles

doi:10.1002/pbc.27770

IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials

Karen M. Chisholm, Jeffrey Mohlman, Michael Liew, Amanda Termuhlen, Mitchell S. Cairo, Thomas G. Gross, Sherrie L. Perkins, Rodney R. Miles

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Abstract

Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.

Original language	English (US)
Article number	e27770
Journal	Pediatric Blood and Cancer
Volume	66
Issue number	8
DOIs	https://doi.org/10.1002/pbc.27770
State	Published - Aug 2019

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Publisher Copyright:
© 2019 Wiley Periodicals, Inc.

Keywords

diffuse large B-cell lymphoma
follicular lymphoma, IRF4
lymphoma
pediatric

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title = "IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials",

abstract = "Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.",

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AU - Chisholm, Karen M.

AU - Mohlman, Jeffrey

AU - Liew, Michael

AU - Termuhlen, Amanda

AU - Cairo, Mitchell S.

AU - Gross, Thomas G.

AU - Perkins, Sherrie L.

AU - Miles, Rodney R.

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N2 - Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.

AB - Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.

KW - diffuse large B-cell lymphoma

KW - follicular lymphoma, IRF4

KW - lymphoma

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IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials

Abstract

Bibliographical note

Keywords

UN SDGs

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