TY - JOUR
T1 - Kidney function and cerebral blood flow
T2 - The Rotterdam study
AU - Sedaghat, Sanaz
AU - Vernooij, Meike W.
AU - Loehrer, Elizabeth
AU - Mattace-Raso, Francesco U.S.
AU - Hofman, Albert
AU - Van Der Lugt, Aad
AU - Franco, Oscar H.
AU - Dehghan, Abbas
AU - Ikram, M. Arfan
PY - 2016/3
Y1 - 2016/3
N2 - CKDis linkedwith various braindisorders.Whereas brain integrity is dependent on cerebral perfusion, the association between kidney function and cerebral blood flow has yet to be determined. This study was performed in the framework of the population-based Rotterdam Study and included 2645 participants with mean age of 56.6 years (45% men). We used EGFR and albumin-to-creatinine ratio to assess kidney function and performed phase-contrast magnetic resonance imaging of basilar and carotid arteries to measure cerebral blood flow. Participants had an average (SD) EGFR of 86.3 (13.4) ml/min per 1.73m2andamedian(interquartile range) albumin-to-creatinine ratio of 3.4 (2.2-6.1)mg/g. In age-and sex-adjustedmodels, a higher albumin-to-creatinine ratio was associated with lower cerebral blood flow level (difference in cerebral blood flow[milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, 20.31; 95% confidence interval, 20.58 to20.03). The association was not present after adjustment for cardiovascular risk factors (P=0.10). Each 1 SD lower EGFR was associatedwith 0.42ml/min per 100 ml lower cerebral blood flow(95% confidence interval, 0.01 to 0.83) adjusted for cardiovascular risk factors. Thus, in this population-based study, we observed that lower EGFR is independently associated with lower cerebral blood flow.
AB - CKDis linkedwith various braindisorders.Whereas brain integrity is dependent on cerebral perfusion, the association between kidney function and cerebral blood flow has yet to be determined. This study was performed in the framework of the population-based Rotterdam Study and included 2645 participants with mean age of 56.6 years (45% men). We used EGFR and albumin-to-creatinine ratio to assess kidney function and performed phase-contrast magnetic resonance imaging of basilar and carotid arteries to measure cerebral blood flow. Participants had an average (SD) EGFR of 86.3 (13.4) ml/min per 1.73m2andamedian(interquartile range) albumin-to-creatinine ratio of 3.4 (2.2-6.1)mg/g. In age-and sex-adjustedmodels, a higher albumin-to-creatinine ratio was associated with lower cerebral blood flow level (difference in cerebral blood flow[milliliters per minute per 100 ml] per doubling of the albumin-to-creatinine ratio, 20.31; 95% confidence interval, 20.58 to20.03). The association was not present after adjustment for cardiovascular risk factors (P=0.10). Each 1 SD lower EGFR was associatedwith 0.42ml/min per 100 ml lower cerebral blood flow(95% confidence interval, 0.01 to 0.83) adjusted for cardiovascular risk factors. Thus, in this population-based study, we observed that lower EGFR is independently associated with lower cerebral blood flow.
UR - http://www.scopus.com/inward/record.url?scp=84959926269&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959926269&partnerID=8YFLogxK
U2 - 10.1681/ASN.2014111118
DO - 10.1681/ASN.2014111118
M3 - Article
C2 - 26251352
AN - SCOPUS:84959926269
SN - 1046-6673
VL - 27
SP - 715
EP - 721
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 3
ER -