TY - JOUR
T1 - Lack of influence of TfC genetic phenotype on iron, iron-binding capacity, percentage saturation, and immunologically determined transferrin in blood donor sera
AU - Eckfeldt, John H
AU - Dykes, Dale D.
AU - Dahl, Irven I.
AU - Skare, Cynthia M.
AU - Polesky, Herbert F.
PY - 1985/1/15
Y1 - 1985/1/15
N2 - Although over 22 different genetic variants of human transferrin have been described, three subtypes of the TfC allele, TfC1, TfC2, and TfC3, have a combined gene frequency of over 0.95 in most US populations. We measured iron, iron-binding capacity, and immunologically determined transferrin in blood donor sera of known TfC phenotypes, since we thought the results might be transferrin phenotype dependent, as is haptoglobin concentration on haptoglobin genetic phenotype. However, we found no major differences in the mean iron, mean iron-binding capacity, mean percentage saturation, or mean immunological transferrin in blood donors of different TfC phenotypes. We also found reasonably good correlation (r = 0.86) between immunologically determined transferrin and chemically determined iron-binding capacity with no significant differences in the linear regression parameters for sera of various TfC phenotypes.
AB - Although over 22 different genetic variants of human transferrin have been described, three subtypes of the TfC allele, TfC1, TfC2, and TfC3, have a combined gene frequency of over 0.95 in most US populations. We measured iron, iron-binding capacity, and immunologically determined transferrin in blood donor sera of known TfC phenotypes, since we thought the results might be transferrin phenotype dependent, as is haptoglobin concentration on haptoglobin genetic phenotype. However, we found no major differences in the mean iron, mean iron-binding capacity, mean percentage saturation, or mean immunological transferrin in blood donors of different TfC phenotypes. We also found reasonably good correlation (r = 0.86) between immunologically determined transferrin and chemically determined iron-binding capacity with no significant differences in the linear regression parameters for sera of various TfC phenotypes.
KW - Iron - binding capacity, Iron transferrin
KW - Iron deficiency anemia
KW - Nutritional status
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U2 - 10.1016/0009-8981(85)90023-3
DO - 10.1016/0009-8981(85)90023-3
M3 - Article
C2 - 3978816
AN - SCOPUS:0021894180
SN - 0009-8981
VL - 145
SP - 101
EP - 105
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
IS - 1
ER -