[Leu31,Pro34]Neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake

David C. Jewett; James Cleary; David W. Schaal; Travis Thompson; Allen S. Levine

doi:10.1016/0006-8993(93)91197-Z

[Leu³¹,Pro³⁴]Neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake

David C. Jewett, James Cleary, David W. Schaal, Travis Thompson, Allen S. Levine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu³¹,Pro³⁴]NPY, a Y₁ receptor agonist and NPY 20-36, Y₂ receptor agonist. [Leu³¹,Pro³⁴]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu³¹,Pro³⁴]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y₁, but not the Y₂, receptor.

Original language	English (US)
Pages (from-to)	129-132
Number of pages	4
Journal	Brain Research
Volume	631
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(93)91197-Z
State	Published - Dec 17 1993

Bibliographical note

Funding Information:
This work was supportedby NIDA GrantsD A02717a nd DA03999 and the Departmenot f VeteransA ffairs. D.C.J. was supported under NIDA TrainingG rantD A07097.T he authorsw ish to thank Martha Grace for her expert technicaal ssistancteh roughoutth e project.

Keywords

Discriminative stimulus
Drug discrimination
Food intake
NPY 20-36
NPY receptor
Neuropeptide Y (NPY)
[Leu,Pro]NPY

Access

10.1016/0006-8993(93)91197-Z

OpenUrl availability

Full text

Cite this

@article{afb1c19ef9ed454f94102e133b8b4ac6,

title = "[Leu31,Pro34]Neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake",

abstract = "Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.",

keywords = "Discriminative stimulus, Drug discrimination, Food intake, NPY 20-36, NPY receptor, Neuropeptide Y (NPY), [Leu,Pro]NPY",

author = "Jewett, {David C.} and James Cleary and Schaal, {David W.} and Travis Thompson and Levine, {Allen S.}",

note = "Funding Information: This work was supportedby NIDA GrantsD A02717a nd DA03999 and the Departmenot f VeteransA ffairs. D.C.J. was supported under NIDA TrainingG rantD A07097.T he authorsw ish to thank Martha Grace for her expert technicaal ssistancteh roughoutth e project.",

year = "1993",

month = dec,

day = "17",

doi = "10.1016/0006-8993(93)91197-Z",

language = "English (US)",

volume = "631",

pages = "129--132",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - [Leu31,Pro34]Neuropeptide Y (NPY), but not NPY 20-36, produces discriminative stimulus effects similar to NPY and induces food intake

AU - Jewett, David C.

AU - Cleary, James

AU - Schaal, David W.

AU - Thompson, Travis

AU - Levine, Allen S.

N1 - Funding Information: This work was supportedby NIDA GrantsD A02717a nd DA03999 and the Departmenot f VeteransA ffairs. D.C.J. was supported under NIDA TrainingG rantD A07097.T he authorsw ish to thank Martha Grace for her expert technicaal ssistancteh roughoutth e project.

PY - 1993/12/17

Y1 - 1993/12/17

N2 - Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.

AB - Rats were trained to discriminate between an intracerebroventricular injection of 1.15 nmol of Neuropeptide Y (NPY) and a sham injection. Rats rapidly learned to press the appropriate lever during training. NPY's discriminative stimulus effects were compared to those of saline, and 1.15-3.45 nmol [Leu31,Pro34]NPY, a Y1 receptor agonist and NPY 20-36, Y2 receptor agonist. [Leu31,Pro34]NPY resulted in NPY-appropriate responding, whereas saline and NPY 20-36 did not. [Leu31,Pro34]NPY also increased food intake, but NPY 20-36 did not. This suggests that NPY's discriminative stimulus and orexigenic effects involve the Y1, but not the Y2, receptor.

KW - Discriminative stimulus

KW - Drug discrimination

KW - Food intake

KW - NPY 20-36

KW - NPY receptor

KW - Neuropeptide Y (NPY)

KW - [Leu,Pro]NPY

UR - http://www.scopus.com/inward/record.url?scp=0027332678&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027332678&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(93)91197-Z

DO - 10.1016/0006-8993(93)91197-Z

M3 - Article

C2 - 8298985

AN - SCOPUS:0027332678

SN - 0006-8993

VL - 631

SP - 129

EP - 132

JO - Brain Research

JF - Brain Research

IS - 1

ER -