Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Jessica L. Nielson; Jenny Haefeli; Ernesto A. Salegio; Aiwen W. Liu; Cristian F. Guandique; Ellen D. Stück; Stephanie Hawbecker; Rod Moseanko; Sarah C. Strand; Sharon Zdunowski; John H. Brock; Roland R. Roy; Ephron S. Rosenzweig; Yvette S. Nout-Lomas; Gregoire Courtine; Leif A. Havton; Oswald Steward; V. Reggie Edgerton; Mark H. Tuszynski; Michael S. Beattie; Jacqueline C. Bresnahan; Adam R. Ferguson

doi:10.1016/j.brainres.2014.10.048

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Jessica L. Nielson, Jenny Haefeli, Ernesto A. Salegio, Aiwen W. Liu, Cristian F. Guandique, Ellen D. Stück, Stephanie Hawbecker, Rod Moseanko, Sarah C. Strand, Sharon Zdunowski, John H. Brock, Roland R. Roy, Ephron S. Rosenzweig, Yvette S. Nout-Lomas, Gregoire Courtine, Leif A. Havton, Oswald Steward, V. Reggie Edgerton, Mark H. Tuszynski, Michael S. BeattieJacqueline C. Bresnahan, Adam R. Ferguson

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into clinical trials, the SCI community has called for a non-human primate model as a crucial validation step to test efficacy and validity of these therapies prior to human testing. The present paper reviews the previous and ongoing efforts of the California Spinal Cord Consortium (CSCC), a multidisciplinary team of experts from 5 University of California medical and research centers, to develop this crucial translational SCI model. We focus on the growing volumes of high resolution data collected by the CSCC, and our efforts to develop a biomedical informatics framework aimed at leveraging multidimensional data to monitor plasticity and repair targeting recovery of hand and arm function. Although the main focus of many researchers is the restoration of voluntary motor control, we also describe our ongoing efforts to add assessments of sensory function, including pain, vital signs during surgery, and recovery of bladder and bowel function. By pooling our multidimensional data resources and building a unified database infrastructure for this clinically relevant translational model of SCI, we are now in a unique position to test promising therapeutic strategies efficacy on the entire syndrome of SCI. We review analyses highlighting the intersection between motor, sensory, autonomic and pathological contributions to the overall restoration of function. This article is part of a Special Issue entitled SI: Spinal cord injury.

Original language	English (US)
Pages (from-to)	124-138
Number of pages	15
Journal	Brain Research
Volume	1619
DOIs	https://doi.org/10.1016/j.brainres.2014.10.048
State	Published - 2015

Bibliographical note

Funding Information:
The authors would like to thank Vladimir Muraru for technical programming support during this project. Funding support was provided by the US National Institutes of Health ( NS42291 , NS049881 , NS053059 , NS067092 , NS069537 , and NS079030 ); Craig H. Neilsen Foundation, Veterans Administration ; California Roman Reed Fund; Bernard and Anne Spitzer Charitable Trust ; Dr Miriam and Sheldon G. Adelson Medical Research Foundation ; and NYS CoRE CO19772 .

Publisher Copyright:
© 2014 Elsevier B.V.

Keywords

Autonomic function
Big-data
Bioinformatics
Motor function
Non-human primate
Plasticity
Recovery
Sensory function
Spinal cord injury
Statistics
Syndromics
Translation

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Nielson, J. L., Haefeli, J., Salegio, E. A., Liu, A. W., Guandique, C. F., Stück, E. D., Hawbecker, S., Moseanko, R., Strand, S. C., Zdunowski, S., Brock, J. H., Roy, R. R., Rosenzweig, E. S., Nout-Lomas, Y. S., Courtine, G., Havton, L. A., Steward, O., Reggie Edgerton, V., Tuszynski, M. H., ... Ferguson, A. R. (2015). Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Research, 1619, 124-138. https://doi.org/10.1016/j.brainres.2014.10.048

Nielson, JL, Haefeli, J, Salegio, EA, Liu, AW, Guandique, CF, Stück, ED, Hawbecker, S, Moseanko, R, Strand, SC, Zdunowski, S, Brock, JH, Roy, RR, Rosenzweig, ES, Nout-Lomas, YS, Courtine, G, Havton, LA, Steward, O, Reggie Edgerton, V, Tuszynski, MH, Beattie, MS, Bresnahan, JC & Ferguson, AR 2015, 'Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury', Brain Research, vol. 1619, pp. 124-138. https://doi.org/10.1016/j.brainres.2014.10.048

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title = "Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury",

abstract = "Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into clinical trials, the SCI community has called for a non-human primate model as a crucial validation step to test efficacy and validity of these therapies prior to human testing. The present paper reviews the previous and ongoing efforts of the California Spinal Cord Consortium (CSCC), a multidisciplinary team of experts from 5 University of California medical and research centers, to develop this crucial translational SCI model. We focus on the growing volumes of high resolution data collected by the CSCC, and our efforts to develop a biomedical informatics framework aimed at leveraging multidimensional data to monitor plasticity and repair targeting recovery of hand and arm function. Although the main focus of many researchers is the restoration of voluntary motor control, we also describe our ongoing efforts to add assessments of sensory function, including pain, vital signs during surgery, and recovery of bladder and bowel function. By pooling our multidimensional data resources and building a unified database infrastructure for this clinically relevant translational model of SCI, we are now in a unique position to test promising therapeutic strategies efficacy on the entire syndrome of SCI. We review analyses highlighting the intersection between motor, sensory, autonomic and pathological contributions to the overall restoration of function. This article is part of a Special Issue entitled SI: Spinal cord injury.",

keywords = "Autonomic function, Big-data, Bioinformatics, Motor function, Non-human primate, Plasticity, Recovery, Sensory function, Spinal cord injury, Statistics, Syndromics, Translation",

author = "Nielson, {Jessica L.} and Jenny Haefeli and Salegio, {Ernesto A.} and Liu, {Aiwen W.} and Guandique, {Cristian F.} and St{\"u}ck, {Ellen D.} and Stephanie Hawbecker and Rod Moseanko and Strand, {Sarah C.} and Sharon Zdunowski and Brock, {John H.} and Roy, {Roland R.} and Rosenzweig, {Ephron S.} and Nout-Lomas, {Yvette S.} and Gregoire Courtine and Havton, {Leif A.} and Oswald Steward and {Reggie Edgerton}, V. and Tuszynski, {Mark H.} and Beattie, {Michael S.} and Bresnahan, {Jacqueline C.} and Ferguson, {Adam R.}",

note = "Funding Information: The authors would like to thank Vladimir Muraru for technical programming support during this project. Funding support was provided by the US National Institutes of Health ( NS42291 , NS049881 , NS053059 , NS067092 , NS069537 , and NS079030 ); Craig H. Neilsen Foundation, Veterans Administration ; California Roman Reed Fund; Bernard and Anne Spitzer Charitable Trust ; Dr Miriam and Sheldon G. Adelson Medical Research Foundation ; and NYS CoRE CO19772 . Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

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AU - Stück, Ellen D.

AU - Hawbecker, Stephanie

AU - Moseanko, Rod

AU - Strand, Sarah C.

AU - Zdunowski, Sharon

AU - Brock, John H.

AU - Roy, Roland R.

AU - Rosenzweig, Ephron S.

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AU - Havton, Leif A.

AU - Steward, Oswald

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AU - Beattie, Michael S.

AU - Bresnahan, Jacqueline C.

AU - Ferguson, Adam R.

N1 - Funding Information: The authors would like to thank Vladimir Muraru for technical programming support during this project. Funding support was provided by the US National Institutes of Health ( NS42291 , NS049881 , NS053059 , NS067092 , NS069537 , and NS079030 ); Craig H. Neilsen Foundation, Veterans Administration ; California Roman Reed Fund; Bernard and Anne Spitzer Charitable Trust ; Dr Miriam and Sheldon G. Adelson Medical Research Foundation ; and NYS CoRE CO19772 . Publisher Copyright: © 2014 Elsevier B.V.

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Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Abstract

Bibliographical note

Keywords

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