Levodopa-induced dyskinesias in Parkinson’s disease

Stephanie L. Alberico; Nandakumar S. Narayanan

doi:10.1016/B978-0-12-815946-0.00032-6

Levodopa-induced dyskinesias in Parkinson’s disease

Stephanie L. Alberico, Nandakumar S. Narayanan

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

A major problem in treating Parkinson’s disease is that up to 80% of patients will develop levodopa-induced dyskinesias (LIDs). These abnormal involuntary movements result in difficulty in controlling movements and contribute to further disability in Parkinson’s disease. Despite the long history of levodopa as the leading therapy, it remains unknown how these abnormal movements develop. In this chapter, we review the pathophysiology of LIDs including recent work implicating different neuronal populations in the striatum.

Original language	English (US)
Title of host publication	Diagnosis and Management in Parkinson’s Disease
Subtitle of host publication	The Neuroscience of Parkinson’s Disease, Volume 1
Publisher	Elsevier
Pages	543-555
Number of pages	13
ISBN (Electronic)	9780128159460
DOIs	https://doi.org/10.1016/B978-0-12-815946-0.00032-6
State	Published - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier Inc.

Keywords

Abnormal involuntary movements
Cholinergic interneurons
Fast spiking interneurons
Levodopa-induced dyskinesia
Medium spiny neurons
Striatum

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Levodopa-induced dyskinesias in Parkinson’s disease

Abstract

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Keywords

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