TY - JOUR
T1 - Lifestyle and Subsequent Malignant Neoplasms in Childhood Cancer Survivors
T2 - A Report from the St. Jude Lifetime Cohort Study
AU - Onerup, Aron
AU - Mirzaei, Sedigheh
AU - Bhatia, Shalini
AU - Åberg, Maria
AU - Ware, Megan E.
AU - Joffe, Lenat
AU - Turcotte, Lucie M.
AU - Goodenough, Chelsea G.
AU - Sapkota, Yadav
AU - Dixon, Stephanie B.
AU - Wogksch, Matthew D.
AU - Ehrhardt, Matthew J.
AU - Armstrong, Gregory T.
AU - Hudson, Melissa M.
AU - Ness, Kirsten K.
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/3
Y1 - 2024/3
N2 - Introduction: This study aimed to assess longitudinal associations between lifestyle and subsequent malignant neoplasms (SMNs) in young adult childhood cancer survivors. Methods: Members of the St. Jude Lifetime Cohort (SJLIFE) aged ≥18 years and surviving ≥5 years after childhood cancer diagnosis were queried and evaluated for physical activity, cardiorespiratory fitness (CRF), muscle strength, body mass index (BMI), smoking, risky drinking, and a combined lifestyle score. Time to first SMN, excluding nonmalignant neoplasms and nonmelanoma skin cancer, was the outcome of longitudinal analysis. Results: Survivors (n = 4072, 47% female, 29% smokers, 37% risky drinkers, 34% obese, and 48% physically inactive) had a mean (SD) time between baseline evaluation and follow-up of 7.0 (3.3) years, an age of 8.7 (5.7) years at diagnosis, and an age of 30 (8.4) years at baseline lifestyle assessment. Neither individual lifestyle factors nor a healthy lifestyle score (RR 0.8, 0.4–1.3, p = 0.36) were associated with the risk of developing an SMN. Conclusions: We did not identify any association between lifestyle factors and the risk of SMN in young adult childhood cancer survivors.
AB - Introduction: This study aimed to assess longitudinal associations between lifestyle and subsequent malignant neoplasms (SMNs) in young adult childhood cancer survivors. Methods: Members of the St. Jude Lifetime Cohort (SJLIFE) aged ≥18 years and surviving ≥5 years after childhood cancer diagnosis were queried and evaluated for physical activity, cardiorespiratory fitness (CRF), muscle strength, body mass index (BMI), smoking, risky drinking, and a combined lifestyle score. Time to first SMN, excluding nonmalignant neoplasms and nonmelanoma skin cancer, was the outcome of longitudinal analysis. Results: Survivors (n = 4072, 47% female, 29% smokers, 37% risky drinkers, 34% obese, and 48% physically inactive) had a mean (SD) time between baseline evaluation and follow-up of 7.0 (3.3) years, an age of 8.7 (5.7) years at diagnosis, and an age of 30 (8.4) years at baseline lifestyle assessment. Neither individual lifestyle factors nor a healthy lifestyle score (RR 0.8, 0.4–1.3, p = 0.36) were associated with the risk of developing an SMN. Conclusions: We did not identify any association between lifestyle factors and the risk of SMN in young adult childhood cancer survivors.
KW - body mass index
KW - cancer
KW - childhood cancer
KW - epidemiology
KW - fitness
KW - physical activity
KW - subsequent malignant neoplasms
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U2 - 10.3390/cancers16050864
DO - 10.3390/cancers16050864
M3 - Article
C2 - 38473225
AN - SCOPUS:85187878959
SN - 2072-6694
VL - 16
JO - Cancers
JF - Cancers
IS - 5
M1 - 864
ER -