Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In

Harald J. Junge

doi:10.1016/j.neuron.2017.08.026

Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In

Harald J. Junge

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes.

Original language	English (US)
Pages (from-to)	983-985
Number of pages	3
Journal	Neuron
Volume	95
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2017.08.026
State	Published - Aug 30 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.

Keywords

Gpr124
Reck
Wnt7
angiogenesis
blood-brain barrier
co-activator
ligand specificity
receptor complex

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuron.2017.08.026

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title = "Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In",

abstract = "CNS angiogenesis and blood-brain barrier integrity are controlled by the canonical Wnt pathway. In this issue of Neuron, Cho et al. (2017) use advanced mouse genetics and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124 and RECK with Wnt receptor complexes.",

keywords = "Gpr124, Reck, Wnt7, angiogenesis, blood-brain barrier, co-activator, ligand specificity, receptor complex",

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KW - angiogenesis

KW - blood-brain barrier

KW - co-activator

KW - ligand specificity

KW - receptor complex

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Ligand-Selective Wnt Receptor Complexes in CNS Blood Vessels: RECK and GPR124 Plugged In

Abstract

Bibliographical note

Keywords

UN SDGs

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