TY - JOUR
T1 - Linking specific biological signatures to different childhood adversities
T2 - findings from the HERO project
AU - on behalf of the JPB Research Network on Toxic Stress
AU - de Mendonça Filho, Euclides José
AU - Pokhvisneva, Irina
AU - Maalouf, Christina Maria
AU - Parent, Carine
AU - Mliner, Shanna B.
AU - Slopen, Natalie
AU - Williams, David R.
AU - Bush, Nicole R.
AU - Boyce, William Thomas
AU - Levitt, Pat
AU - Nelson, Charles A.
AU - Gunnar, Megan R.
AU - Meaney, Michael J.
AU - Shonkoff, Jack P.
AU - Silveira, Patricia Pelufo
N1 - Publisher Copyright:
© 2022, The Author(s).
PY - 2023/8
Y1 - 2023/8
N2 - Background: Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited. Methods: Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145). Results: Children exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample. Conclusions: Our results indicate that these biological response systems may react differently to different forms of early-life adversity. Impact: Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking.Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA.Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage.Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities. [Figure not available: see fulltext.].
AB - Background: Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited. Methods: Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145). Results: Children exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample. Conclusions: Our results indicate that these biological response systems may react differently to different forms of early-life adversity. Impact: Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking.Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA.Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage.Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities. [Figure not available: see fulltext.].
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U2 - 10.1038/s41390-022-02415-y
DO - 10.1038/s41390-022-02415-y
M3 - Article
C2 - 36650307
AN - SCOPUS:85146307322
SN - 0031-3998
VL - 94
SP - 564
EP - 574
JO - Pediatric Research
JF - Pediatric Research
IS - 2
ER -