Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism

Yuanyuan Zhang; Hong Guo; Jessica A. Deis; Mara G. Mashek; Ming Zhao; Donsanjiv Ariyakumar; Anibal G. Armien; David A. Bernlohr; Douglas G. Mashek; Xiaoli Chen

doi:10.1074/jbc.M114.559104

Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism

Yuanyuan Zhang, Hong Guo, Jessica A. Deis, Mara G. Mashek, Ming Zhao, Donsanjiv Ariyakumar, Anibal G. Armien, David A. Bernlohr, Douglas G. Mashek, Xiaoli Chen

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Lipocalin 2 is a recently characterized adipokine/cytokine known to be a critical regulator of metabolic homeostasis. Results: Lcn2 deficiency impairs BAT activation by reducing peroxisomal and mitochondrial oxidation of lipids and the recruitment of functional brown adipocytes. Conclusion: We demonstrate a novel role of Lcn2 in oxidative metabolism and BAT activation via a nonadrenergic pathway. Significance: Our findings advance understanding of the adrenergic independent mechanism for BAT activation.

Original language	English (US)
Pages (from-to)	22063-22077
Number of pages	15
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.559104
State	Published - Aug 8 2014

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title = "Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism",

abstract = "Background: Lipocalin 2 is a recently characterized adipokine/cytokine known to be a critical regulator of metabolic homeostasis. Results: Lcn2 deficiency impairs BAT activation by reducing peroxisomal and mitochondrial oxidation of lipids and the recruitment of functional brown adipocytes. Conclusion: We demonstrate a novel role of Lcn2 in oxidative metabolism and BAT activation via a nonadrenergic pathway. Significance: Our findings advance understanding of the adrenergic independent mechanism for BAT activation.",

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AU - Zhang, Yuanyuan

AU - Guo, Hong

AU - Deis, Jessica A.

AU - Mashek, Mara G.

AU - Zhao, Ming

AU - Ariyakumar, Donsanjiv

AU - Armien, Anibal G.

AU - Bernlohr, David A.

AU - Mashek, Douglas G.

AU - Chen, Xiaoli

PY - 2014/8/8

Y1 - 2014/8/8

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AB - Background: Lipocalin 2 is a recently characterized adipokine/cytokine known to be a critical regulator of metabolic homeostasis. Results: Lcn2 deficiency impairs BAT activation by reducing peroxisomal and mitochondrial oxidation of lipids and the recruitment of functional brown adipocytes. Conclusion: We demonstrate a novel role of Lcn2 in oxidative metabolism and BAT activation via a nonadrenergic pathway. Significance: Our findings advance understanding of the adrenergic independent mechanism for BAT activation.

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Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism

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