Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Juliane Junesch; Gustav Emilsson; Kunli Xiong; Shailabh Kumar; Takumi Sannomiya; Hudson Pace; Janos Vörös; Sang Hyun Oh; Marta Bally; Andreas B. Dahlin

doi:10.1039/c5nr04208a

Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Juliane Junesch, Gustav Emilsson, Kunli Xiong, Shailabh Kumar, Takumi Sannomiya, Hudson Pace, Janos Vörös, Sang Hyun Oh, Marta Bally, Andreas B. Dahlin

Electrical and Computer Engineering

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Original language	English (US)
Pages (from-to)	15080-15085
Number of pages	6
Journal	Nanoscale
Volume	7
Issue number	37
DOIs	https://doi.org/10.1039/c5nr04208a
State	Published - Oct 7 2015

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© 2015 The Royal Society of Chemistry.

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abstract = "The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic {"}nanowells{"} provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.",

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AU - Junesch, Juliane

AU - Emilsson, Gustav

AU - Xiong, Kunli

AU - Kumar, Shailabh

AU - Sannomiya, Takumi

AU - Pace, Hudson

AU - Vörös, Janos

AU - Oh, Sang Hyun

AU - Bally, Marta

AU - Dahlin, Andreas B.

PY - 2015/10/7

Y1 - 2015/10/7

N2 - The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

AB - The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic "nanowells" provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

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Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

Abstract

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