Mammary gland macrophages: Pleiotropic functions in mammary development

Kathryn L. Schwertfeger; Jeffrey M. Rosen; Donald A. Cohen

doi:10.1007/s10911-006-9028-y

Mammary gland macrophages: Pleiotropic functions in mammary development

Kathryn L. Schwertfeger, Jeffrey M. Rosen, Donald A. Cohen

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Mammary gland development is a complex process involving epithelial cells and supporting stromal cells. Macrophages (MØs) are an important component of the mammary gland stroma and are critical for normal mammary gland development; however, the mechanisms by which macrophages regulate these processes are not well understood. MØs are known to interact with numerous cell types, including epithelial cells, fibroblasts, adipocytes, and endothelial cells, all of which are significant components of mammary gland development. Therefore, the purpose of this review is to describe the interactions between MØs and these various cell types and use this knowledge to identify potential functions of MØs in the mammary gland.

Original language	English (US)
Pages (from-to)	229-238
Number of pages	10
Journal	Journal of mammary gland biology and neoplasia
Volume	11
Issue number	3-4
DOIs	https://doi.org/10.1007/s10911-006-9028-y
State	Published - Oct 2006

Bibliographical note

Funding Information:
Acknowledgments K.L.S. was supported by a Ruth L. Kirschstein National Research Service Award (CA 097676). This work was supported by NIH grant CA16303 to J.M.R. and NIH grant R01 HL69459 and the Kentucky Lung Cancer Research Program to D.A.C.

Keywords

Development
Epithelium
Macrophage
Mammary gland
Stroma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Mammary gland macrophages: Pleiotropic functions in mammary development",

abstract = "Mammary gland development is a complex process involving epithelial cells and supporting stromal cells. Macrophages (M{\O}s) are an important component of the mammary gland stroma and are critical for normal mammary gland development; however, the mechanisms by which macrophages regulate these processes are not well understood. M{\O}s are known to interact with numerous cell types, including epithelial cells, fibroblasts, adipocytes, and endothelial cells, all of which are significant components of mammary gland development. Therefore, the purpose of this review is to describe the interactions between M{\O}s and these various cell types and use this knowledge to identify potential functions of M{\O}s in the mammary gland.",

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AU - Rosen, Jeffrey M.

AU - Cohen, Donald A.

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KW - Stroma

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Mammary gland macrophages: Pleiotropic functions in mammary development

Abstract

Bibliographical note

Keywords

UN SDGs

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